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Clarification of involvement of oxidative stress in development of diabetes mellitus
Prof.Ryoichi Takayanagi et al. are studying about mechanisms of production of oxidative stress in diabetes. They found that the tissue renin-angiotensin system and protein kinase C are activated in hyperglycemia, and stimulate the NDA(P)H oxidase activity resulting in injury of both vessels in all organs and beta-cells in pancreas. They are challenging to make a new drug to suppress the oxdative stress in diabetes mellitus.

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