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例)研究発表 生命科学科

セミナー第38回生命医科学セミナー【カルガリー大学 Dr. Derrick E. Rancourt】

  • [開催日時]2017年3月3日(金)17:30-19:00
  • [開催場所]総合研究棟1階 102講義室
  • [対象]
演 題:Tumorigenecity of iPSCs: New clues for engineering cancer.

演 者: Dr. Derrick E. Rancourt
          Depts. of Med. Biochem., Oncol., and Med. Genet.,
          The University of Calgary

日 時:平成29年3月3日(金)17:30~19:00
場 所:病院地区総合研究棟1階 102講義室
Others have suggested that the cancer phenotype may be erased via cellular reprogramming. Several cancer cell lines have been reprogrammed previously to varying degrees; however, it remains unclear if cancer cells can be fully reprogrammed into induced pluripotent stem cells (iPSCs) that can form benign teratomas, and if cancer-specific epigenetic alterations are erased during this process. We investigated if mammary cancer stem cell (CSC), derived from Her2/Neu over-expressing transgenic mice, can be fully reprogrammed into iPSCs.
We also tested whether the reprogrammed CSCs lose or retain their potential to form tumors in vivo by means of becoming pluripotent. We show that the reprogrammed breast CSCs can be terminally differentiated into mammary epithelial cells, and that tumorigenicity is retained during differentiation in this microenvironment. Reprogramming of cancer cells is a promising new research approach may offer new possibilities in modeling cancer in vitro.
共 催:福岡医学会
問合せ:九州大学大学院 医学研究院 基礎放射線医学分野 續 輝久(内線6141)