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セミナー第754生医研セミナー【The Hong Kong University of Science and Technology Prof. Danny Leung】

  • [開催日時]2017年11月28日(火)16:00-17:00
  • [開催場所]本館1階 会議室
  • [対象]
備考・問合せ先
 第754生医研セミナー(多階層生体防御システム研究拠点)

下記の通り、香港科技大学のDanny Leung先生によるセミナーを開催致します。講演
は英語で行われます。
皆様のご来聴を心より歓迎いたします。

演題: Epigenetic regulation of non-coding DNA in development and diseases
        【Seminar in English】
演者: Prof. Danny Leung
        Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China
日時: 2017年11月28日(火) Nov. 28 (Tue), 2017
        16:00~17:00
場所: 病院キャンパス 生体防御医学研究所本館1階 会議室
        以下の地図の26番です。
    
Seminar room, Main Building 1F, Medical Institute of Bioregulation
No.26 building on the following linked map.
    
http://www.kyushu-u.ac.jp/f/30078/Hospital_jp-2017.pdf

    
要旨:
While the genome encodes the blueprint for mammalian development, it is the epigenome that allows this code to be interpreted uniquely by each cell-type. Deciphering the epigenome will reveal insights into a plethora of biological processes. Our research focuses on epigenetic mechanisms that regulate transcription of non-coding DNA sequence. Using high-throughput genomic techniques, we generated extensive profiles of epigenetic modifications, gene expression, and chromatin conformation for various cell-types. We discovered unique characteristics and roles of non-coding elements in shaping the gene expression networks important for distinct cell-type identity and function. Specifically, we aim to delineate the contributions of endogenous retroviruses, a class of repetitive genomic sequences, in normal developmental programs as well as disease states such as cancer.

1. Leung et al. Integrative analysis of haplotype-resolved epigenomes across human tissues. Nature 518, 350-354 (2015) 2. Leung et al. Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1.
PNAS 111, 6690-6695 (2014)

連絡先: Division of Epigenomics and Development, MIB, Hiroyuki SASAKI

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