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セミナー第759回生医研セミナー【医学研究院 岡田先生】

  • [開催日時]2018年1月29日(月)9:30-10:30
  • [開催場所]生医研 本館1階 会議室
  • [対象]


演題:Spinal cord regeneration based on glial biology(Seminar in English)

演者:岡田 誠司 先生 Seiji Okada, M.D., Ph.D.
        九州大学医学研究院 先端医療医学部門 准教授
        Associate Professor
        Dept.of Advanced Medical Initiatives
        Graduate School of Medical Sciences,Kyushu University


場所:病院キャンパス 生体防御医学研究所 本館1階 会議室
        Seminar Room, Main Building 1F,
        Medical Institute of Bioregulation

In recent years, stem cell transplantation has emerged as a potential therapeutic strategy for spinal cord injury (SCI), and several early-phase clinical trials have been completed. However, its efficacy and long-term safety remain unproven,
especially in the chronic transplantation for SCI. One of the failure causes can be ascribed to the glial scar, which strictly segregates the lesion and the spared area after SCI. The process of glial scar formation, astrogliosis, has long been considered to be unidirectional and irreversible, however, we recently demonstrated that the process of glial scar formation is regulated by environmental cues, such as fibrotic extracellular matrix material. In this seminar, I will talk about the new concept for spinal cord regeneration based on glial biology.

1.Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Harimaya K,
   Nakashima Y, Okada S*. Interaction of reactive astrocytes with collagen type I induces
   astrocytic scar formation through the integrin/N-cadherin pathway after spinal cord injury.
   Nature Medicine. 23:818-28, 2017.
2.Koabayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Yokota K, Ideta R, Shiba K,
   Inoue K, Iwamoto Y, Okada S*. Acute hyperglycemia impairs functional improvement after
   spinal cord injury in mice and humans. Science Transl. Med. 6:256ra137, 2014.