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セミナー第764回生医研セミナー【Dr. Jean-Marc Schwartz Senior Lecturer Faculty of Biology, Medicine and Health】

  • [開催日時]2018年1月22日(月)16:00-17:00
  • [開催場所]総合研究棟1F 105セミナー室
  • [対象]
備考・問合せ先
第764回 生医研セミナーのご案内です。
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日時:
平成30年1月22日(月)16:00~17:00

場所:
総合研究棟1F 105セミナー室

演題:
Applications of systems and network approaches to the investigation of human diseases

演者:
Dr. Jean-Marc Schwartz
Senior Lecturer
Faculty of Biology, Medicine and Health     
University of Manchester, UK

要旨:
Network and systems-based approaches are increasingly used to study dysregulated molecular components in diseases. By modelling the relations between genes/proteins in an integrative way, we can gain better understanding of the processes and pathways involved in disorders and infer their causal regulators, paving the way for the development of new treatments. In this seminar, we will describe different approaches enabling us to model disease systems. First, we will present a Boolean modelling technique applied to understand the mechanisms of action of Herceptin, a drug which is widely used to treat breast cancer but whose action is hampered in some cases by the development of resistance in tumour cells. Next, we will present an integration of network analysis with gene expression (RNA-sequencing) data applied to the study of skeletal diseases, and show how this integration helps to discover new pathways and regulators involved in these disorders.
Reference:
Hetmanski et al (2016). A MAPK-driven feedback loop suppresses Rac activity to promote RhoA-driven cancer cell invasion. PLoS Computational Biology 12: e1004909.
Schwartz et al (2015). Metabolic flux prediction in cancer cells with altered substrate uptake. Biochem Soc Trans 43: 1177-81.
Soul et al (2015). PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes. Scientific Reports 5: 8117.

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