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セミナー第763回生医研セミナー【Dr. Emmanuel Barillot Director of Department Institut Curie - INSERM U900 - PSL Resear】

  • [開催日時]2018年1月19日(金)16:00-17:00
  • [開催場所]総合研究棟2F 204セミナー室
  • [対象]
備考・問合せ先
第763回 生医研セミナーのご案内です。
ご興味のある皆様方のご来聴を心より歓迎申し上げます。

日時:
平成30年1月19日(金)16:00~17:00

場所:
総合研究棟2F 204セミナー室

演題:
Computational oncology: is it data-driven or knowledge driven?

演者:
Dr. Emmanuel Barillot
Director of Department
Institut Curie - INSERM U900 - PSL Research University / Mines ParisTech, FRANCE

要旨:
While molecular and phenotypic data about tumors and models are accumulating at an ever-increasing pace, the bottleneck in cancer research has shifted from data acquisition to computational analysis.
What is missing to translate our research into clinical benefit for the patient? Should we focus on knowledge-driven or data-driven approaches?
My talk will give examples of both, in particular for single cell analysis, knowledge formalisation and network modelling. Applications will concern among others: Ewing sarcoma, colon carcinoma, and metastasis formation.
Reference:
Chanrion et al (2014) Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. Nature communications 5: 10.
Biton et al (2014) Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and Basal subtypes. Cell reports 9: 4. 1235-1245.

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