DEPARTMENT OF CARDIOVASCULAR MEDICINE KYUSHU UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES

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Research Units

Molecular Cardiology Unit

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menu Research Outline Main Research Themes and Relevant Publications Principle Investigator of the group Staff and Research Focus

Principle Investigator of the group


Toshihiro Ichiki, M.D., Ph.D.

Toshihiro Ichiki, M.D., Ph.D.Dr. Toshihiro Ichiki graduated from Kyushu University School of Medicine in 1987. He became a graduate student of Graduate School of Medical Sciences, Kyushu University in 1989, and was engaged in research on class switch of immunoglobulin genes at the Medical Institute of Bioregulation (Dr. Takeshi Watanabe, Professor Emeritus). From 1993 he studied abroad at the Department of Biochemistry, Vanderbilt University School of Medicine (Professor Tadashi Inagami), engaging in research on angiotensin II receptor, especially type 2 receptor. He succeeded in producing mice deficient in angiotensin II type 2 receptor (Nature 1995 ;377:748-750), for which he was awarded the F. Merlin Bumpus Memorial Award from AHA High Blood Pressure Research Council.

In 1995 he joined the Department of Cardiovascular Medicine of Kyushu University School of Medicine as a clinical fellow, researching mainly on the regulation of angiotensin II type 1 receptor expression and its signaling pathway. He analyzed the roles of cAMP response element binding protein (CREB) as a molecule transducing the angiotensin II signals, as well as the serine/threonine kinase known as Rho-kinase. In 1998 he joined the Department of Coronary Care Unit of Kyushu University Hospital as a Research Associate and was later promoted to Assistant Professor.

From 2008 he was appointed Associate Professor at the Department of Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University. In recognition of his continuous works on angiotensin II receptor, he was awarded the 2008 commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology. In addition to the research on angiotensin II receptor, he is currently expanding his research to the study on the actions of longevity gene in blood vessels and also angiogenesis.

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