2009年発表論文
Tajima T, Fujiwara F, Fujieda K: A novel heterozygous mutation of steroidogenic factor-1 (SF-1/Ad4BP) gene (NR5A1) in a 46, XY disorders of sex development (DSD) patient without adrenal failure. Endocr J, in press
Fukami M, Nishimura G, Homma K, Nagai T, Hanaki K, Uematsu A, Ishii T, Numakura C, Sawada H, Nakacho M, Kowase T, Motomura K, Haruna H, Nakamura M, Ohishi A, Adachi M, Tajima T, Hasegawa Y, Hasegawa T, Horikawa R, Fujieda K, Ogata T: Cytochrome P450 Oxidoreductase Deficiency: Identification and Characterization of Biallelic Mutations and Genotype-Phenotype Correlations in 35 Japanese Patients. J Clin Endocrinol Metab. 2009, in press
2008年発表論文
Okuhara K, Abe S, Kondo T, Fujita K, Koda N, Mochizuki H, Fujieda K, Tajima T: Four Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism caused by DAX-1 gene mutations: mutant DAX-1 failed to repress steroidogenic acute regulatory protein (StAR) and luteinizing hormone beta-subunit gene promoter activity. Endocr J. 55, 97-103, 2008
2007年発表論文
Sugawara T, Nomura E, Hoshi N: Cholesterol sulphate affects production of steroid hormones by reducing steroidogenic acute regulatory protein level in adrenocortical cells. J Endocrinol. 195, 451-458, 2007
2006年発表論文
Warita K, Sugawara T, Yue ZP, Tsukahara S, Mutoh K, Hasegawa Y, Kitagawa H, Mori C, Hoshi N: Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice. J Vet Med Sci. 68, 1257-1267, 2006
Sugawara T, Sakuragi N, Minakami H: CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP. J Endocrinol. 191, 339-348, 2006
Hughes IA, Houk C, Ahmed SF, Lee PA, LWPES/ESPE Consensus Group (Fujieda K, et al): Consensus statement on management of intersex disorders. Arch Dis Child. 91, 554-563, 2006
Both N-terminal and C-terminal regions of steroid sulphatase are important for enzyme activity. T. Sugawara, E. Nomura, N. Hoshi J. Endocrinol. 188, 365-374, 2006
2005年発表論文
Franzese A, Brunetti-Pierri N, Spadaro R, Mukai T, Valerio G: Inappropriate tall stature and renal ectopy in a male patient with X-linked congenital adrenal hypoplasia due to a novel missense mutation in the DAX-1 gene. Am J Med Genet. 135A, 72-74, 2005
K. Fujieda, T. Tajima : Molecular basis of adrenal insufficiency. Pediatr. Res. 57, 62-69, 2005
M. Fukami, F. Kato, T. Tajima, S. Yokoya, T. Ogata : Transactivation function of -800 bp evolutionarily conserved sequence at the SHOX 3' region. Implication for the downstream enhancer. Am. J. Hum. Genet. 78, 167-170, 2005
2004年発表論文
Sugawara T, Nomura E, Nakajima A, Sakuragi N: Characterization of binding between SF-1 and Sp1: predominant interaction of SF-1 with the N-terminal region of Sp1. J Endocrinol Invest. 27, 133-141, 2004
C.E. Fluck, T. Tajima, A.V. Pandey, W. Arlt, K. Okuhara, C.F. Verge, E.W. Jabs, B.B. Mendonca, K. Fujieda, W.L. Miller. : Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nature Genet. 36, 228-230, 2004
A.V. Pandey, C.E. Fluck, N. Huang, T. Tajima, K. Fujieda, W.L. Miller : P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes. Endocri. Res. 30, 881-888, 2004
T. Sugawara : Role of StAR binding protein in steroidogenic cells. Endocri. Res. 30, 695, 2004
Sugawara T, Hoshi N, Sakuragi N: Immunohistochemical study of steroidogenic acute regulatory (StAR) protein in ovarian tumors. The Internet Journal of Gynecology and Obstetrics. 3, 2, 2004
T. Sugawara, E. Nomura, A. Nakajima, N. Sakuragi : Characterization of binding between SF-1 and Sp1: predominant interaction of SF-1 with the N-terminal region of Sp1. J. Endocrinol. Inv. 27, 133-141, 2004
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