文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

秦 健一郎 HATA, Ken-ichirou
国立成育医療センター研究所 周産期病態研究部
研究項目A01 「性分化の分子基盤の解析」
研究課題 哺乳類配偶子の雌雄差を規定する分子機構の解明

2007年発表論文

Kato, Y., Kaneda, M., Hata, K., Kumaki, K., Hisano, M., Kohara, Y., Okano, M., Li, E., Nozaki, M., and Sasaki, H. Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet 16, 2272-2280, 2007

2006年発表論文

Nimura, K., Ishida, C., Koriyama,H., Hata, K., Yamanaka, S., Li, E., Ura, K. and Kaneda, Y. Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells. in press

Arima, T., Hata, K., Tanaka, S., Kusumi, M., Li, E., Kato, K., Shiota, K., Sasaki, H. and Wake, N. Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev. Biol. in press

Yokomine, T., Hata, K., Tsudzuki, M. and Sasaki, H. Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting. Cytogenet. Genome Res., 113, 75-80, 2006

Xie, Z.H., Huang, Y.N., Chen, Z.X., Riggs, A.D., Ding, J.P., Gowher, H., Jeltsch, A., Sasaki, H., Hata, K. and Xu, G.L. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum. Mol. Genet., 15, 1375-1385, 2006

Hata, K., Kusumi, M., Yokomine, T., Li, E. and Sasaki, H. Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Mol. Reprod. Dev., 73, 116-122, 2006

Arnaud, P., Hata, K., Kaneda, M., Li, E., Sasaki, H., Feil, R. and Kelsey, G. Stochastic imprinting in the progeny of Dnmt3L-/- females. Hum. Mol. Genet., 15, 589-598 2006

2004年発表論文

Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E and Sasaki H. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429: 900-903, 2004