文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

秦野 修 HATANO, Osamu
奈良県立医科大学 医学部
研究項目A03 「性分化異常症の解析」
研究課題 未分化性腺の形成の分子機構と性分化との関連

2007年発表論文

Takemori H, Kajimura J, Okamoto M. TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. FEBS J. 274, 3202-3209, 2007

Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 13, 597-603, 2007

SjÖstrÖm M, StenstrÖm K, Eneling K, Zwiller J, Katz AI, Takemori H, Bertorello AM. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proc Natl Acad Sci U S A. 104,16922-27, 2007

Takemori H, Kanematsu M, Kajimura J, Hatano O, Katoh Y, Lin XZ, Min L, Yamazaki T, Doi J, Okamoto M. Dephosphorylation of TORC initiates expression of the StAR gene. Mol Cell Endocrinol. 26, 196-204, 2007

2006年発表論文

Zhou Y, Wu H, Li S, Chen Q, Cheng XW, Zheng J, Takemori H, Xiong ZQ. Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus.  PLoS ONE. 1, e16, 2006

Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M. Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.  FEBS J. 273, 2730-2748, 2006

Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M, Placzek M. Regional morphogenesis in the hypothalamus : a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation.   Dev Cell. 11, 873-885, 2006

2005年発表論文

Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437, 1109-1111, 2005

Kagawa N, Senbonmatsu TA, Satoh K, Ichihara K, Yamagata N, Hatano O, Saito T, Nguyen VQ, Waterman MR, Price E Jr, Atkinson JB, Inagami T. Tetracycline protects myocardium against ischemic injury. Front Biosci. 10:608-619, 2005

2004年発表論文

Min L, Takemori H, Nonaka Y, Katoh Y, Doi J, Horike N, Hatano O, Raza FS, Vinson GP, Okamoto M. Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis. Mol Cell Endocrinol. 215:143-148, 2004