文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

東 雄二郎 HIGASHI, Yujiro
愛知県心身障害者コロニー発達障害研究所 周生期学部
研究項目A03 「性分化異常症の解析」
研究課題 外生殖器形成過程におけるZFHX1転写制御因子ファミリーの機能

2009年発表論文

Bui, T., Sequeira, J., Wen, T.-C., Sola, A., Higashi, Y., Kondoh, H. and Genetta, T. ZEB1 Links p63 and p73 in a Novel Neuronal Survival Pathway Rapidly Induced in Response to Cortical Ischemia. PLoS ONE 4, e4373,2009

Inuzuka, T., Tsuda, M., Tanaka, S., Kawaguchi, H., Higashi, Y. and Ohba, Y. Integral Role of Transcription Factor 8 in the Negative Regulation of Tumor Angiogenesis. Cancer Research 69, 1678-1684, 2009

2008年発表論文

Hidaka, H., Nakahata, S., Hatakeyama, K., Hamasaki, M., Yamashita, K., Kohno, T., Arai, Y., Taki, T., Nishida, K., Okayama, A., Asada, Y., Yamaguchi, R., Tsubouchi, H., Yokota, J., Taniwaki, M., Higashi, Y. and Morishita, K. Down-regulation of TCF8 is involved in the leukemogenesis of adult-T cell leukemia/lymphoma. Blood 15, 383-393, 2008

Jin, J.-Z., Li, Q., Higashi, Y., Darling, D. S. and Ding, J. Analysis of Zfhx1a mutant mice reveals palatal shelf contact independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 333, 29-38, 2008

Liu Y, El-Naggar S, Darling D. S., Higashi Y., Dean D. C. Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 135, 579-588, 2008

2007年発表論文

Liu, Y., Costantino, M. E., Montoya-D., D., Higashi, Y., Darling, D. S. and Dean, D. C. The zinc finger transcription factor, ZFHX1A, is linked to cell proliferation by Rb/E2F1. Biochem, J. 408, 79-85, 2007

Miquelajauregui, A., Van de Putte, T., Polyakov, P., Nityanandam, A., Boppana, S., Karabinos, A., Seuntjens, E., Higashi, Y., Huylebroeck, D. and Tarabykin, V. Smad-interacting protein-1 (Sip1/Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation Proc. Natl. Acad. Sci. USA, 104, 12919-12924, 2007