文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

星 信彦 HOSHI, Nobuhiko
神戸大学 大学院農学研究科
研究項目A03 「性分化異常症の解析」
研究課題 性分化異常症における性の決定・分化の分子細胞遺伝機構の解明

2009年発表論文

Mitsuhashi, T., Warita, K, Sugawara, T., Tabuchi, Y., Takasaki, I., Kondo, T., Hayashi, F., Takeuchi, Y., Miki, T., Matsumoto, Y., Wang, Z.-Y., Ebina, Y., Yamada, H., Sakuragi, N., Yokoyama, T., Nanmor,i T., Kitagawa, H., Kant, J. A., Hoshi, N. Hyperacetylation and upregulation of SRY in the XY female patient. Journal of Clinical Investigation, 2009, submitted

Tanida, T., Warita, K. Ishihara, K., Fukui S, Mitsuhashi, T., Sugawara, T., Tabuchi, Y., Nanmori, T., Qi, W.-M., Inamoto, T., Yokoyama, T., Kitagawa, H. and Hoshi, N. Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: Mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. Toxicology Letters, 2009, in press

Tanida, T., Warita, K., Mitsuhashi, T., Ishihara, K., Yokoyama, T., Kitagawa, H. and Hoshi N. Morphological analyses of age-related changes in C3H mouse midbrain. Journal of Veterinary Medical Science, 71, 2009, in press

2008年発表論文

Warita, K., Okamoto, K., Mutoh, K., Hasegawa, Y., Yue, Z-P., Qi, W-M., Kitagawa, H., Sugawara, T. and Hoshi, N. Activin A and eCG recover reproductive dysfunction induced by neonatal exposure to estrogenic endocrine disruptor in adult male mice. Biology of Reproduction, 78, 59-67, 2008

2007年発表論文

Ishihara, K., Warita, K., Tanida, T., Sugawara, T., Kitagawa, H. and Hoshi, N. Does paternal exposure to 2,3,7,8-tetrachlorodi benzo-p-dioxin (TCDD) affect the sex ratio of offspring? Journal of Veterinary Medical Science, 69, 347-352, 2007

Sugawara, T., Nomura, E. and Hoshi, N. Cholesterol sulphate affects production of steroid hormones by reducing steroidogenic acute regulatory protein level in adrenocortical cells. Journal of Endocrinology, 195, 451-458, 2007

2006年発表論文

Warita, K., Sugawara, T., Yue, Z-P., Tsukahara, S., Mutoh, K., Hasegawa, Y., Kitagawa, H., Mori, C. and Hoshi, N. Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice. Journal of Veterinary Medical Science, 68, 1257-1267, 2006

Sugawara, T., Nomura, E. and Hoshi, N. Both N-terminal and C-terminal regions of steroid sulphatase are important for enzyme activity. Journal of Endocrinology, 188, 365-374, 2006

2005年発表論文

Tsukahara, S., Tanaka, S., Ishida, K., Hoshi, N. and Kitagawa, H. Age-related change and its sex differences in histoarchitecture of the hypothalamic suprachiasmatic nucleus of F344/N rat. Experimental Gerontology, 40: 147-55, 2005.

2004年発表論文

Hoshi, N., Okuyama, K., Yamada, H., Yamada, T., Sugawara, T., Sagawa, T. and Fujimoto, S. Familial 15p tetrasomy due to extra supernumerary marker 15 chromosome associated with Robertsonian translocation between chromosomes 13 and 14. Chromosome Science, 7: 7-13, 2004.