文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

大谷-金子 律子 OHTANI-KANEKO, Ritsuko
東洋大学 生命科学部
研究項目A02 「脳の性分化と行動の解析」
研究課題 周生期の視床下部シナプス形成に及ぼすエストロゲンの作用と作用機序(平成17年度〜平成18年度)
     脳の性差発現機構の解明(平成19年度〜平成20年度)

2009年発表論文

Tsukahara S: Sex differences and roles of sex steroids in apoptosis of sexually dimorphic nuclei of preoptic area in postnatal rats. Journal of Neuroendocrinology, 21, 370-376, 2009

Ogasawara K, Nogami H, Mumeko C. Tsuda, J-Å, Gustafsson K, Korach S, Ogawa S, Harigaya T, and Hisano S. Hormonal regulation of prolactin cell development in the fetal pituitary gland of the mouse. Endocrinology 150, 1061-8, 2009

2008年発表論文

Ohtani-Kaneko R, Tazawa H, Yokosuka M, Yoshida M, Satoh M, Watanabe C. Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells. Toxicology. 253, 110-6, 2008

Munemasa Y, Kitaoka Y, Hayashi Y, Takeda H, Fujino H, Ohtani-Kaneko R, Hirata K, Ueno S. Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage. Vis Neurosci. 25, 197-208, 2008

Fujisawa H, Ohtani-Kaneko R, Naiki M, Okada T, Masuko K, Yudoh K, Suematsu N, Okamoto K, Nishioka K, Kato T. Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis. Proteomics 8, 1706-19, 2008

Yokosuka M, Ohtani-Kaneko R*, Yamashita K, Muraoka D, Kuroda Y, Watanabe C. Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias. Toxicolgy In Vitro. 22, 1-9, 2008

Cushing BS, Perry A, Musatov S, Ogawa S, Papademetriou E. Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior . J. Neurosci. 28, 10399-403, 2008

Kavaliers M, Devidze N, Choleris E, Fudge M, Gustafsson JA, Korach KS, Pfaff DW, Ogawa S*. Estrogen receptors alpha and beta mediate different aspects of the facilitatory effects of female cues on male risk taking. Psychoneuroendocrinology. 33, 634-42, 2008

Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M. Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain type creatine kinase as novel autoantigens. Molecular Vision. 14, 1094-1104, 2008

Tsukahara S, Hojo R, Kuroda Y, & Fujimaki H: Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats. Neuroscience Letters, 432, 58-63, 2008

Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M.: Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain type creatine kinase as novel autoantigens.: Molecular Vision 14, 1094-1104, 2008

2007年発表論文

Kato T, Ohtani-Kaneko R, Shiga T. Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. Neurosci Research. 58, 402-405, 2007

Hayashi Y, Kitaoka Y, Munemasa Y, Ohtani-Kaneko R, Kikusui T, Uematsu A, Takeda H, Hirata K, Mori Y, Ueno S. Neuroprotective effect of 17β-estradiol against NMDA-induced retinal neurotoxicity via p-ERK induction. Journal of Neuroscience Research 85, 386-494, 2007

Musatov, S., Chen, W., Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G., and Ogawa, S*. Silencing of estrogen receptor a in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci, U.S.A., 104, 2501-2507, 2007

Agmo, A.*, Choleris, E., Kavaliers, M., Pfaff, D.W., and Ogawa, S*. Social and sexual incentive properties of estrogen receptor alpha, estrogen receptor beta, or oxytocin knockout mice. Genes Brain Behav, 7, 70-77, 2007

Yamakawa K, Yoshida K, Nishikawa H, Kato T, Iwamoto T.: Comparative analysis of interindividual variations in the seminal plasma proteome of fertile men with identification of potential markers for azoospermia in infertile patien.: J Andrology 28, 858-865, 2007

Masuko K, Murata M, Xiang Y, Nakamura H, Yudoh K, Nishioka K, Beppu M, Kato T.: Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes.: Clin Exp Rheumatol 25, 860-865, 2007

Xiang Y, T. Matsui, K. Matsuo, K. Shimada, S. Tohma, H. Nakamura, K. Masuko, K. Yudoh, K. Nishioka and T. Kato. Comprehensive investigation of disease-specific short peptides in sera from patients with systemic sclerosis: Complement C3f-des-arginine, detected predominantly in systemic sclerosis sera, enhances proliferation of vascular endothelial cells.: Arthritis Rheum 56, 2018-2030, 2007

2006年発表論文

Munemasa Y., Ohtani-Kaneko R., Kitaoka Y., Kumai T., Kitaoka Y., Hayashi Y., Watanabe M., Takeda H., Hirata K. and Ueno S. Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina. J. Neurosci. Res. 83, 907-918, 2006

Kamijo-Ikemori A, Sugaya T, Obama A, Hiroi J, Miura H, Watanabe M, Kumai T, Ohtani-Kaneko R, Hirata K, Kimura K. Liver-type Fatty Acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction. American Journal of Pathology 169, 1107-1117, 2006

Ohtani-Kaneko R. Mechanisms underlying estrogen-induced sexual differentiation in the hypothalamus. Histol. Histopathol. 21, 317-324, 2006

2005年発表論文

Hiroi J., Miyazaki H., Katoh F., Ohtani-Kaneko R. and Kaneko T. Chloride turnover and ion-transporting activities of yolk-sac preparations (yolk balls) separated from Mozambique tilapia embryos and incubated in freshwater and seawater. J. Exp. Biol. 208, 3851-3858, 2005

Igarashi-Migitaka J., Takeshita A., Koibuchi N., Yamada S., Ohtani-Kaneko R. and Hirata K. Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Eur. J. Endocrinol. 153, 595-604, 2005

Hiroi J., McCormick S.D., Ohtani-Kaneko R. and Kaneko T. Functional classification of mitochondrion-rich cells in euryhaline Mozambique tilapia (Oreochromis mossambicus) embryos, by means of triple immunofluorescence staining for Na+/K+-ATPase, Na+/K+/2Cl- cotransporter and CFTR anion channel. J. Exp. Biol. 208, 2023-2036, 2005

Munemasa Y., Ohtani-Kaneko R., Kitaoka Y, Kuribayashi K., Isenoumi K., Kogo J., Yamashita K., Kumai T., Kobayashi S., Hirata K. and Ueno S. Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina. Brain Res. 24, 1044, 227-240, 2005

Kato T., Ohtani-Kaneko R., Ono K., Okado N. and Shiga T. Developmental regulation of activated ERK expression in the spinal cord and dorsal root ganglion of the chick embryo. Neurosci. Res. 52, 11-19, 2005

Hayami R., Sato K., Wu W., Nishikawa T., Hiroi J., Ohtani-Kaneko R., Fukuda M. and Ohta T. Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. Cancer Res. 65, 6-10, 2005