文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

北野 健 KITANO, Takeshi
熊本大学 大学院自然科学研究科
研究項目A01 「性分化の分子基盤の解析」
研究課題 温度依存性の分子メカニズム

2008年発表論文

Shiraishi E., Yoshinaga N., Miura T., Yokoi H., Wakamatsu Y., Abe S. and Kitano T. Mullerian inhibiting substance is required for germ cell proliferation during early gonadal differentiation in medaka (Oryzias latipies). Endocrinology, 149, 1813-1819, 2008

Yazawa T., Uesaka M., Inaoka Y., Mizutani T., Sekiguchi T., Kajitani T., Kitano T., Umezawa A. and Miyamoto K. Cyp11b1 is induced in the murine gonad by luteinizing hormone/ human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen; conservation and evolution of androgen metabolic pathway. Endocrinology, 149. 1786-1792, 2008

Satone H., Oshima Y., Shimasaki Y., Tawaratsumita T., Oba Y., Takahashi E., Kitano T., Kawabata S., Kakuta Y. and Honjo T. Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus.  Aquatic Toxicology, 90, 292-299, 2008

Yamaguchi T. and Kitano T. The mechanism of transcriptional regulation of P450 aromatase gene by Foxl2 in Japanese flounder (Paralichthys olivaceus). Cybium, 32 (suppl) , 74-76, 2008

Shirozu T., Shiraishi E., Yoshinaga N., Yamaguchi T. and Kitano T. The mechanism of transcriptional regulation of Mullerian inhibiting substance in Japanese flounder (Paralichthys olivaceus). Cybium, 32 (suppl) , 90-91, 2008

Shimada H., Yasutake A., Hirashima T., Takamure Y., Kitano T., Waalkes M.P. and Imamura Y. Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats. Toxicology in Vitro, 22, 338-343, 2008

Jin Y., Uchida I., Eto K., Kitano T. and Abe S.-I. Size-selective junctional barrier and Ca2+ independent cell adhesion in the testis of Cynops pyrrhogaster: expression and function of occludin. Mol. Reprod. Dev., 75, 202-216, 2008

2007年発表論文

Yamaguchi T., Yamaguchi S., Hirai T. and Kitano T. Follicle-stimulating hormone signaling and Foxl2 are involved in transcriptional regulation of aromatase gene during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus. Biochem. Biophys. Res. Commun., 359, 935-940, 2007

Oba Y., Shimasaki Y., Oshima Y., Satone H., Kitano T., Nakao M., Kawabata S. and Honjo T. Purification and characterization of tributyltin binding protein type 2 from plasma of Japanese flounder, Paralichthys olivaceus. J. Biochem., 142, 229-238, 2007

Hano T., Oshima Y., Kim S. G., Satone H., Oba Y., Kitano T., Inoue S., Shimasaki Y. and Honjo T. Tributlyltin causes abnormal development in embryo of medaka, Oryzias latipes. Chemosphere, 69, 927-933, 2007

Kitano T., Yoshinaga N., Shiraishi E., Koyanagi T. and Abe S.-I. Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and M?llerian inhibiting substance mRNA expression in Japanese flounder (Paralichthys olivaceus). Mol. Reprod. Dev., 74, 1171-1177, 2007

Shimada H., Imaishi K., Hirashima T., Kitano T., Ishikura S., Hara A. and Imamura Y. Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrate. Life Sci., 80, 554-558, 2007

2006年発表論文

Takeshi Kitano, Norifumi Yoshinaga, Eri Shiraishi, Takashi Koyanagi and Shin-ichi Abe. Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and M?llerian inhibiting substance mRNA expression in Japanese flounder (Paralichthys olivaceus). Mol. Reprod. Dev. (In press)

Yutaka Kawakami, Dong-Hwan Shin, Takeshi Kitano, Shinji Adachi, Kohei Yamauchi and Hiromi Ohta. Transactivation activity of thyroid hormone receptors in fish (Conger myriaster) in response to thyroid hormones. Comp. Biochem. Physiol. B (In press)

Takeshi Kitano, Takashi Koyanagi, Ryuta Adachi, Nao Sakimura, Kazufumi Takamune and Shin-ichi Abe. Assessment of estrogenic chemicals using an estrogen receptor α (ERα)- and ERβ-mediated reporter gene assay in fish. Mar. Biol. 149, 49-55, 2006

2005年発表論文

Nakata, H., Hirakawa, Y., Kawazoe, M., Nakabo, T., Arizono, K., Abe, S., Kitano, T., Shimada, H., Watanabe, I., Li W. and Ding, X. Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from lake Tai, Hangzhou bay and Shanghai city region, China. Environmental Pollution 133, 415-429, 2005

Nakata, H., Nasu, T., Abe, S., Kitano, T., Fan, Q., Li W. and Ding, X. Organochlorine contaminants in human adipose tissues from China: mass balance approach for estimating historical exposure to DDTs by Chinese.Environmental Science and Technology 39 (13) ,4714 -4720, 2005

2004年発表論文

Shiraishi, E., Imazato, H., Yamamoto, T., Yokoi, H., Abe, S. and Kitano, T. Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes). Mechanisms of Development 121, 991-996, 2004

Yoshinaga, N., Shiraishi, E., Yamamoto, T., Iguchi, T., Abe, S. and Kitano, T. Sexually dimorphic expression of a teleost homologue of Mullerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus. Biochemical and Biophysical Research Communications 322, 508-513, 2004