2009年発表論文
Ryuji Hiramatsu, Shogo Matoba, Masahiko Fujisawa, Masami Kanai-Azuma, Naoki Tsunekawa, Masamichi Kurohmaru, Ken-ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai.
A critical time window of Sry action in gonadal sex determination.
Development 136, 129-138, 2009
2008年発表論文
Mohamad Zubair, Keith L. Parker, and Ken-ichirou Morohashi.
Developmental links between fetal and adult adrenal cortex revealed by lineage tracing.
Mol Cell Biol 28, 7030-7040, 2008
Noriko Sakai, Hiromi Terami, Shinobu Suzuki, Megumi Haga, Ken Nomoto, Nobuko Tsuchida, Ken-ichirou Morohashi, Naoaki Saito, Maki Asada, Megumi Hashimoto, Daisuke Harada, Hiroshi Asahara, Tetsuya Ishikawa, Fumiki Shimada, Kazuhiro Sakurada.
Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.
J Endocrinol 198, 489-497, 2008
Yuichi Shima, Mohamad Zubair, Tomoko Komatsu, Sanae Oka, Chikako Yokoyama, Taro Tachibana, Tord A Hjalt, and Ken-ichirou Morohashi.
Pitx2 directly regulates Ad4BP/SF-1 gene transcription in the pituitary gonadotrope via interaction with the intronic enhancer.
Mol Endocrinol 22, 1633-1646, 2008
Yuko Sato, Takashi Baba, Mohamad Zubair, Kanako Miyabayashi, Yoshiro Toyama, Mamiko Maekawa, Akiko Owaki, Hirofumi Mizusaki1, Tatsuya Sawamura, Kiyotaka Toshimori, Ken-ichirou Morohashi*, and Yuko Katoh-Fukui.
Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
Mol Repro Dev 75, 1361-1371, 2008
(* corresponding author)
Takashi Baba, Yuichi Shima, Junsei Mimura, Motohiko Oshima, Yoshiaki Fujii-Kuriyama, and Ken-ichirou Morohashi.
Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice.
Sex Dev 2, 1-11, 2008
Yoshiyasu Ishimaru, Tomoko Komatsu, Megumi Kasahara, Yuko Katoh-Fukui, Yoshiro Toyama, Mamiko Maekawa, Kiyotaka Toshimori, Roshantha A. S. Chandraratna, Ken-ichirou Morohashi*, and Hidefumi Yoshioka*.
Mechanism of asymmetric ovarian development in chick embryos.
(*; The last two authors equally contributed to this work.)
Development 135, 677-685, 2008
Yoshiyuki Kojima, Yutaro Hayashi, Kentaro Mizuno, Shoichi Sasaki, Yuko Fukui, Peter Koopman, Ken-Ichirou Morohashi and Kenjiro Kohri.
Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males.
Clin. Endocrinol. 68, 791-799, 2008
2007年発表論文
Takashi Baba, Yuichi Shima, Junsei Mimura, Motohiko Oshima, Yoshiaki Fujii-Kuriyama, and Ken-ichirou Morohashi. Involvement of aryl hydrocarbon receptor (AhR) in maintenance of seminal vesicle through sexually different target gene expression. Sexual Development in press
Maki Fukami, Yuka, Wada, Michiyo Okada, Fumiko Kato, Noriyuki Katsumata, Takashi Baba, Ken-ichirou Morohashi, Jocelyn Laporte, Motoo Kitagawa, and Tsutomu Ogata. Mastermind-like domain containing 1 (MAMLD1 or Cxorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. J. Biol. Chem. In press
Yuko Sato, Takashi Baba, Mohamad Zubair, Kanako Miyabayashi, Yoshiro Toyama, Mamiko Maekawa, Akiko Owaki, Hirofumi Mizusaki1, Tatsuya Sawamura, Kiyotaka Toshimori, Ken-ichirou Morohashi, and Yuko Katoh-Fukui. Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature. Mol. Repro. Dev. In press
Yoshiyasu Ishimaru, Tomoko Komatsu, Megumi Kasahara, Yuko Katoh-Fukui, Yoshiro Toyama, Mamiko Maekawa, Kiyotaka Toshimori, Roshantha A. S. Chandraratna, Ken-ichirou Morohashi, and Hidefumi Yoshioka (*; The last two authors equally contributed to this work.) Mechanism of asymmetric ovarian development in birds. Development in press
Yoshiyuki Kojima, Yutaro Hayashi, Shoichi Sasaki, Peter Koopman, Ken-ichirou Morohashi, and Kenjiro Kohri. Clinical and molecular analyses of SRY-negative XX male patients -Correlation between clinical findings and expression of transcription factors implicated in gonadal sex differentiation- Clin. Endocrinol. In press
Hiromi Kurokawa, Daisuke Saito, Yuko Katoh-Fukui, Kohei Ohta, Takashi Baba, Ken-ichirou Morohashi, and Minoru Tanaka. Germ cells are essential for sexual dimorphism in the medaka gonad. Pro. Natl. Acad. Sci. USA 104, 16958-16963, 2007.
Yuki Ohmuro-Matsuyama, Kataaki Okubo, Masaru Matsuda, Shigeho Ijiri, Deshou Wang, Guijun Guan, Taiga Suzuki, Makoto Matsuyama, Ken-ichirou Morohashi, and Yoshitaka Nagahama. Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes.
Mol. Repro. Dev 74, 1065-1071, 2007.
WuQiang Fan, Toshihiko Yanase, Hidetaka Morinaga, Shigeki Gondo, Taijiro Okabe, Masatoshi Nomura, Tomoko Komatsu, Ken-Ichirou Morohashi, Tyrone B. Hayes, Ryoichi Takayanagi, and Hajime Nawata. Atrazine-induced aromatase expression is SF-1-dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans. Environmental Health Perspectives 115, 720-727, 2007
De-Shou Wang, Tohru Kobayashi, Lin-Yan Shou, Yuki Ohmuro-Matsuyama, Gui-Jun Guan, Shigeho Ijiri, Funie Sakai, Masaru Matsuda, Yasushi Shibata, Kataaki Okubo, Ken-chirou Morohashi, and Yoshitaka Nagahama. Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with Ad4BP/SF-1. Mol. Endocrinol. 21, 712-725, 2007
Naoko Sato, Yusuke Kamachi, Hisato Kondoh, Yuichi Shima, Ken-ichirou Morohashi, Reiko Horikawa and Tsutomu Ogata. Hypogonadotropic hypogonadism in an adult female with a heterozygous hypomorphic mutation of SOX2. Eur. J. Endocrinol. 156, 169-173, 2007
2006年発表論文
Maki Fukami, Yuka Wada, Kanako Miyabayashi, Ichizo Nishino, Tomonobu Hasegawa, Giovanna Camerino, Christine Kretz, Anna Buj-Bello, Jocelyn Laporte, Gen Yamada,Ken-ichirou Morohashi, and Tsutomu Ogata. CXorf6 is a causative gene for hypospadias. Nature Genetics 38, 1369-1371, 2006
Yoshiyuki Kojima, Shoichi Sakaki, Yutaro Hayashi, Yukihiro Umemoto, Ken-ichirou Morohashi, and Kenjiro Kohri. Role of transcription factors Ad4BP/SF-1 and DAX-1 in steroidogenesis and spermatogenesis in human testicular development and idiopathic azospermia. Int. J. Urol. 13, 785-793, 2006
M. Zubair, S. Ishihara, S. Oka, K. Okumura, K. Morohashi. Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development; initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1. Mol. Cell. Biol. 26, 4111-4121, 2006
Fatchiyah, M. Zubair, Y. Shima, S. Oka, S. Ishihara, Y. Fukui-Katoh, K. Morohashi. Differential Gene Dosage Effects of Ad4BP/SF-1 on Target Tissue Development. Biochem. Biophys. Res. Commun. 341, 1036-1045, 2006
2005年発表論文
Takashi Baba, Junsei Mimura, Naohito Nakamura, Nobuhiro Harada, Masayuki Yamamoto, Ken-ichirou Morohashi* and Yoshiaki Fujii-Kuriyama* (*; The last two authors equally contributed to this work.) Ah (dioxin) receptor as a key factor in the regulation of female reproduction. Mol. Cell. Biol. 25, 10040-10051, 2005
Yuichi Shima, Mohamad Zubair, Satoru Ishihara, Yuko Shinohara, Sanae Oka, Shioko Kimura, Sachiyo Suita, and Ken-ichirou Morohashi. VMH specific enhancer of Ad4BP/SF-1 gene. Mol. Endocrinol. 19, 2812-2823, 2005
Kamei Y, Aoyama Y, Fujimoto T, Kenmotsu N, Kishi C, Koushi M, Sugano S, Morohashi K, Kamiyama R, Asakai R. A steroidogenic cell line with differentiation potential from mouse granulosa cells, transfected with Ad4BP and SV40 large T antigen genes. J. Endocrinol. 185, 187-195, 2005
Yuko Katoh-Fukui, Akiko Owaki, Yoshirou Sotoyama, Masatomo Kusaka, Yuko Shinohara, Mamiko Maekawa, Kiyotaka Toshimori, and Ken-ichirou Morohashi. Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF-1 expression. Blood.106 ,1612-1620,2005
Makoto Matsuyama, Hirofumi Mizusaki, Akihiko Shimono, Tokuo Mukai, Katsuzumi Okumura, Kuniya Abe, Kiyoshi Shimada, and Ken-ichirou Morohashi. Novel Isoform of Vinexin, Vinexin Regulates Sox9 Gene Expression through activating MAPK Cascade in Mouse Fetal Gonad. Genes to Cells 10, 421-434, 2005
Hidefumi Yoshioka, Yoshiyasu Ishimaru, Noriyuki Sugiyama, Naoki Tsunekawa, Toshiaki Noce, Megumi Kasahara, and Ken-ichirou Morohashi. Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. Dev. Biol. 280, 150-161, 2005
Satoru Ishihara and Ken-ichirou Morohashi. Identification of the boundary for histone acetylation between nuclear receptor genes, Ad4BP/SF-1 and GCNF, aligned in tandem. Biochem. Biophys. Res. Commun. 329, 554-562, 2005
Katsumi Toda, Yoshihiro Hayashi, Teruhiko Okada, Ken-ichirou Morohashi, and Toshiji Saibara. Expression of the estrogen-inducible EGFP gene in aromatase-deficient mice reveals differential tissue-response to estrogenic compounds. Mol. Cell. Endocrinol. 229, 119-126, 2005
2004年発表論文
Tomonobu Hasegawa, Maki Fukami, Naoko Sato, Goro Sasaki, Keiko Fukutani, Ken-ichirou Morohashi, and Tsutomu Ogata. Testicular Dysgenesis without Adrenal Insufficiency in a 46,XY Patient with a Heterozygous Inactive Mutation of Steroidogenic Factor-1. J. Clin. Endocrinol. Metab. 89, 5930-5935, 2004
Tomoko Komatsu, Hirofumi Mizusaki, Tokuo Mukai, Hidesato Ogawa, Daichi Baba, Masahiro Shirakawa, Shigetsugu Hatakeyama, Kei-ichi Nakayama, Hideki Yamamoto, Akira Kikuchi, and Ken-ichirou Morohashi. SUMO-1 Modification of the Synergy Control Motif of Ad4BP/SF-1 Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9. Mol. Endocrinol. 18, 2451-2462, 2004
Hidesato Ogawa, Ruth T. Yu, Tokuko Haraguchi, Yasushi Hiraoka, Yoshihiro Nakatani, Ken-ichirou Morohashi and Kazuhiko Umesono. Nuclear structure-associated TIF2 interacts with glucocorticoid receptor and its target DNA. Biochem. Biophys. Res Commun. 320, 218-225, 2004
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