文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

小川 園子 OGAWA, Sonoko
筑波大学 大学院人間総合科学研究科
研究項目A02 「脳の性分化と行動の解析」
研究課題 行動の性分化とその神経内分泌学的基礎

2009年発表論文

Tomihara, K., Soga, T., Nomura, M., Korach, K.S., Gustafsson, J-Å, Pfaff, D.W., and Ogawa, S. Effect of ER-β gene disruption on estrogenic regulation of anxiety in female mice. Physiology and Behavior, 96, 300-306, 2009

2008年発表論文

Ogasawara, K., Nogami, H., Tsuda, M.C. Gustafsson, J.-Å., Korach, K.S., Ogawa, S., Harigaya, T., and Hisano S. Hormonal regulation of prolactin cell development in the fetal pituitary gland of the mouse. Endocrinology, 150, 1061-1068, 2008

Kavaliers, M., Devidze, N., Choleris, E., Fudge, M., Gustafsson, J.-Å., Korach, K.S., Pfaff, D.W., and Ogawa, S. 2008 Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking. Psychoneuroendocrinology, 33, 634-642, 2008

Cushing, B.S., Perry, A., Musatov, S., Ogawa, S. and Papademetriou E. Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior. Journal of Neuroscience, 28, 10399-10403, 2008

2007年発表論文

Agmo, A., Choleris, E., Kavaliers, M., Pfaff, D.W., and Ogawa, S. Social and sexual incentive properties of estrogen receptor alpha, estrogen receptor beta, or oxytocin knockout mice. Genes Brain and Behavior, 7, 70-77, 2007

Musatov, S., Chen, W., Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G., and Ogawa, S. Silencing of estrogen receptor a in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proceedings of the National Academy of Sciences, U.S.A., 104, 2501-2507, 2007

2006年発表論文

M. Kavaliers, E. Choleris, A. Agmo, W.J. Braun, D.D. Colwell, L.J. Muglia, S. Ogawa and D.W. Pfaff. Inadvertent social information and the avoidance of parasitized male mice: A role for oxytocin. Proc. Natl. Acad. Sci. 103, 4293-4298, 2006.

M. Nomura, S. Andersson, K.S. Korach, J-Ǻ. Gustafsson, D.W. Pfaff and S. Ogawa. Estrogen receptor-β gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice. Eur. J. Neurosci. 23, 1860-1868, 2006.

S.A. Musatov, W. Chen, D.W. Pfaff, M. Kaplitt and S. Ogawa. Knockdown of estrogen receptor α using viral-mediated RNA interference abolishes female sexual behavior. Proc. Natl. Acad. Sci. 103, 10456-10460, 2006.

E. Choleris, S. Ogawa, M. Kavaliers, J-Ǻ. Gustafsson, K.S. Korach, L.J. Muglia and D.W. Pfaff. Involvement of estrogen receptor α, β, and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice. Genes, Brain Behav. in press.

K. Tomihara, T. Kaitsuka, T. Soga, K.S. Korach, D.W. Pfaff, K. Takahama and S. Ogawa. Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor α knockout mice. Neuroreport in press.

2005年発表論文

M. Nomura, K. Akama, S.E. Alves, K.S. Korach, J- Ǻ. Gustafsson, D.W. Pfaff and S. Ogawa. Differential distribution of estrogen receptor (ER)-α and ER-β in the midbrain raphe nuclei and periaqueductal gray in male mouse: predominant role of ER-&beta in midbrain serotonergic systems. Neuroscience 130, 445-456, 2005

I.S. Parhar, T. Soga, S. Ogawa, D.W. Pfaff and Y. Sakuma. Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats. Proc. Natl. Acad. Sci. 102, 5880-5885, 2005.

G. Cataldo, S. Bernal, A. Markowitz, S. Ogawa, A. Ragnauth, D.W. Pfaff and R.J. Bodnar. Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: Effects of adult ovariectomy and estradiol replacement. Brain Res. 1059, 13-19, 2005.

M. Kavaliers, A. Agmo, E. Choleris, L.J. Muglia, S. Ogawa and D.W. Pfaff. Involvement of the oxytocin gene in the recognition and avoidance of parasitized males by female mice. Anim. Behav. 70, 693-702, 2005.

Crews, D., Lou, W., Fleming, A., and Ogawa, S. From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior. Brain Research, 1126, 109-121, 2006