文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

篠田 晃 SHINODA, Koh
山口大学 大学院医学系研究科
研究項目A02 「脳の性分化と行動の解析」
研究課題 性腺・副腎系ホルモンによる脳内ステロイド受容体発現とモノアミン作動系の制御
     (平成17年度〜平成18年度)
     ステロイドによる内側視索前野・扁桃体弓領域内アロマテースとステロイド受容体制御
     (平成19年度〜平成20年度)

2009年発表論文

Kawano J, Fujinaga R, Yamamoto-Hanada K, Oka Y, Tanizawa Y, Shinoda K. Wolfram syndrome 1 (Wfs1) mRNA expression in the normal mouse brain during postnatal development. Neurosci Res. 2009, in press

Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y. Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice. Diabetologia. 2009, in press

2008年発表論文

Zhao C, Fujinaga R, Yanai A, Kokubu K, Takeshita Y, Watanabe Y, Shinoda K. Sex-steroidal regulation of aromatase mRNA expression in adult male rat brain: a quantitative non-radioactive in situ hybridization study. Cell Tissue Res. 332, 381-391, 2008

Kawano J, Tanizawa Y, Shinoda K. Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system. J Comp Neurol. 510, 1-23, 2008

Marumoto Y, Terai S, Urata Y, Matsumoto T, Mizunaga Y, Yamamoto N, Jin H, Fujisawa K, Murata T, Shinoda K, Nishina H, Sakaida I. Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem Biophys Res Commun. 367, 546-552, 2008 Epub 2008 Jan 7.

2007年発表論文

Isobe-Harima Y, Terai S, Miura I, Segawa M, Murata T, Itamoto K, Taura Y, Shinoda K, Sakaida I. A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder. Liver Int. 28, 117-125, 2008 Epub 2007 Oct 26.

Fujinaga R, Yanai A, Nakatsuka H, Yoshida K, Takeshita Y, Uozumi K, Zhao C, Hirata K, Kokubu K, Nagano M, Shinoda K. Anti-human placental antigen complex X-P2 (hPAX-P2) anti-serum recognizes C-terminus of huntingtin-associated protein 1A common to 1B as a determinant marker for the stigmoid body. Histochem Cell Biol. 128, 335-348, 2007

Zhao C, Fujinaga R, Tanaka M, Yanai A, Nakahama K, Shinoda K. Region-specific expression and sex-steroidal regulation on aromatase and its mRNA in the male rat brain: Immunohistochemical and in situ hybridization analyses. J Comp Neurol. 500, 557-573, 2007

Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Murata T, Mizunaga Y, Yamamoto N, Nishina H, Shinoda K, Sakaida I. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res. 327, 463-470, 2007

2006年発表論文

Takeshita Y, Fujinaga R, Zhao C, Yanai A, Shinoda K. Huntingtin-Associated Protein 1 (HAP1) Interacts with Androgen Receptor (AR) and Suppresses SBMA-Mutant-AR-Induced Apoptosis. Hum Mol Genet. 2006 (in press)

Funakoshi T, Yanai A, Shinoda K, Kawano MM, Mizukami Y. G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun., 346:904-910, 2006

Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Sakaida I, Murata T, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K. Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res., Feb;323(2):221-31, 2006

2005年発表論文

Ueda1, K., J. Kawano, K. Takeda, T. Yujiri, K. Tanabe, T. Anno, M. Akiyama, J. Nozaki, T. Yoshinaga, A. Koizumi, K. Shinoda, Y. Oka, and Y. Tanizawa (2005) Endoplasmic Reticulum Stress Induces Wfs1 Gene Expression in Pancreatic β-cells via Transcriptional Activation. Eur J Endocrinol., Jul;153(1):167-76, 2005

2004年発表論文

Fujinaga, R., J. Kawano, Y. Matsuzaki, K. Kamei, A. Yanai, Z. Sheng, M. Tanaka, K. Nakahama, M. Nagano and K. Shinoda. Neuroanatomical distribution of Huntingtin-associated protein 1 (Hap1)-mRNA in the Male mouse brain. J. Comp. Neurol. 478:88-109, 2004

Sheng, Z., J. Kawano, A. Yanai, R. Fujinaga, M. Tanaka, Y. Watanabe and K. Shinoda. Expressions of estrogen receptors (α,β) and androgen receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei; sex and species differences. Neurosci. Res. 49:185-196, 2004

Liu, Y., Y. Ishida, K. Shinoda, S. Furukawa, S. Nakamura. Opposite morphological responses of partially denervated cortical serotonergic and noradrenergic axons to repeated stress in adult rats. Brain Res. Bull. 64:67-74, 2004

Yamamoto, N., S. Terai, S. Ohata, T. Watanabe, K. Omori, K. Shinoda, K. Miyamoto, T. Katada, I. Sakaida, H. Nishina, and K. Okita. A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochem. Biophys. Res. Comm. 313 1110-1118, 2004

Omori, K., S. Terai , T. Ishikawa , T. Ishikawa, K. Aoyama, I. Sakaida, H. Nishina, K. Shinoda, S. Uchimura, Y. Hamamoto, and K. Okita. Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression. FEBS Letters, 578:10-20, 2004