文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

杉本 幸彦 SUGIMOTO, Yukihiko
京都大学 大学院薬学研究科
研究項目A02 「脳の性分化と行動の解析」
研究課題 プロスタグランジンE2による視索前野スパイン形成と性行動発現の分子基盤

2009年発表論文

Tsuchiya,S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., and Sugimoto, Y. Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method. BMC Genomics 10, 35, 2009

2008年発表論文

Tamba, S., Yodoi, R., Segi-Nishida, E., Ichikawa, A., Narumiya, S., and Sugimoto, Y. Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. Proc. Natl. Acad. Sci. USA, 105, 14539-14544, 2008

Tsuchiya, H., Oka, T., Nakamura, K., Ichikawa, A., Saper, C. B., and Sugimoto, Y. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. J. Biol. Chem., 283, 11064-11071, 2008

Esumi, S., Wu, S-X., Yanagawa, Y., Obata, K., Sugimoto, Y., and Tamamaki, N. Method for single-cell microarray analysis and application to gene-expression profiling of GABAergic neuron progenitors. Neurosci. Res., 60, 439-451, 2008

Yellon, S. M., Ebner, C. A., and Sugimoto, Y. Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor. Biol. Reprod., 78, 438-444, 2008

Kawamata, M., Yoshida, M. Sugimoto, Y., Kimura, T., Tonomura, Y., Takayanagi, Y., Yanagisawa, T., and Nishimori, K. Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice. Mol. Cell. Endocrinol., 283, 32-37, 2008

2007年発表論文

Hoshino, T., Nakaya, T., Homan, T., Tanaka, K., Sugimoto, Y., Araki, W., Narita, M., Narumiya, S., Suzuki, T., and Mizushima, T. Involvement of prostaglandin E2 in production of amyloid-peptides both in vitro and in vivo. J. Biol. Chem., 282, 32676-32688, 2007

Suzuki-Yamamoto, T., Sugimoto, Y., Ichikawa, A., and Ishimura, K. Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells. Histochem. Cell Biol., 128, 317-322, 2007

Kawamata, M., Tonomura, Y., Kimura, T., Sugimoto, Y., Yanagisawa, T., and Nishimori, K. Oxytocin-induced phasic and tonic contractions are modulated by the contractile machinery rather than the quantity of oxytocin receptor. Am. J. Physiol. Endocrinol. Metab., 292, E992-E999, 2007

2006年発表論文

H. Kim, H. Arakawa, N. Hatae, , Y. Sugimoto, O. Matsumoto, T. Osada, , A. Ichikawa, and A. Ikai. Quantification of the number of EP3 receptors on a living CHO cell surface by the AFM. Ultramicroscopy. in press 2006

Yokoyama, U., Minamisawa, S., Hong, Q., Ghatak, S., Akaike, T., Segi-Nishida, E., Iwasaki, S., Iwamoto, M., Misra, S., Tamura, K., Hori, H., Yokota, S., Toole, B.P., Sugimoto, Y., and Ishikawa, Y. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J. Clin. Invest., 116, 3026-3034, 2006

2005年発表論文

Y. Shoji, M. Takahashi, N. Takasuka, N. Niho, T. Kitamura, H. Sato, T. Maruyama, Y. Sugimoto, S. Narumiya, T. Sugimura, and K. Wakabayashi. Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. Carcinogenesis 26, 2116-2122, 2005

Y. Liu, K. Furuta, R. Teshima, N. Shirata, Y. Sugimoto, A. Ichikawa, and S. Tanaka. Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. J. Biol. Chem. 280, 38976-38981, 2005

Y. Sugimoto, Y. Fukada, D. Mori, S. Tanaka, H. Yamane, Y. Okuno, K. Deai, S. Tsuchiya, G. Tsujimoto, and A. Ichikawa. Prostaglandin E2 stimulates granulocyte-colony stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils. J. Immunol. 175, 2606-2612, 2005

Takasaki, I., Nojima, H., Shiraki, K., Sugimoto, Y., Ichikawa, A., Ushikubi, F., Narumiya, S., and Kuraishi, Y. Involvement of cyclooxygenase-2 and EP(3) prostaglandin receptor in acute herpetic but not postherpetic pain in mice. Neuropharmacology, 2005 in press

Kunikata, T., Yamane, H., Segi, E., Matsuoka, T., Sugimoto, Y., Tanaka, S., Tanaka, H., Nagai, H., Ichikawa, A., and Narumiya, S. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nature Immunol. 6, 524-531, 2005

Moriyama, T., Higashi, T., Togashi, K., Iida, T., Segi, E., Sugimoto, Y., Tominaga, T., Narumiya, S., and Tominaga, M. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Molecular Pain. 1, 3, 2005

Foyouzi, N., Cai, Z., Sugimoto, Y., and Stocco, C. Changes in the expression of steroidgenic and antioxidant genes in the mouse corpus luteum during luteolysis. Biol. Reprod. 72,1134-1141, 2005

Tanaka, S., Mikura, S., Hashimoto, E., Sugimoto, Y., and Ichikawa, A. Ca(2+) influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE. Eur. J. Immunol. 35, 460-468, 2005

Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., Tsujimoto, G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nature Med. 11, 90-94, 2005

2004年発表論文

Tsuboi, H., Sugimoto, Y., Kainoh, T, and Ichikawa, A. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322, 1066-1072, 2004

Sugimoto, Y., Tsuboi, H., Okuno, Y., Tamba, S., Tsuchiya, S., Tsujimoto, G., and Ichikawa, A. Microarray evaluation of EP4 receptor mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322, 911-917, 2004

Sugimoto, Y., Nakato, T., Kita, A., Takahashi, Y., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. J. Biol. Chem. 279, 11016-11026, 2004

Tanaka, S., Deai, K., Konomi, A., Takahashi, K., Yamane, H., Sugimoto, Y., Ichikawa, A. Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes. Eur. J. Immunol. 34, 1472-1482, 2004

Shoji, Y., Takahashi, M., Kitamura, T., Watanabe, K., Kawamori, T., Maruyama, T., Sugimoto, Y., Negishi, M., Narumiya, S., Sugimura, T., and Wakabayashi, K. Down-regulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut. 53, 1151-1158, 2004