文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

高橋 淑子 TAKAHASHI, Yoshiko
奈良先端科学技術大学院大学 バイオサイエンス研究科
研究項目A01 「性分化の分子基盤の解析」
研究課題 生殖巣の初期形成を支えるダイナミズム

2009年発表論文

Watanabe, W., Sato, Y., Saito, D., Tadokoro, R., and *Takahashi, Y.: Ephrin B2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. Proc. Natl. Acad. Sci. USA, in press

2008年発表論文

Sato, Y. and *Takahashi., Y. (Review) Applications of Tol2 transposon-mediated gene transfer for stable integration and conditional expression of electroporated genes in chicken embryos. In “Electroporation and Sonoporation in Developmental Biology”, Edited by Nakamura, Springer, 17-24

Ohata, E. and *Takahashi, Y. (Review) In ovo electroporation for targeting the somitic mesoderm. In “Electroporation and Sonoporation in Developmental Biology”, Edited by H. Nakamura, Springer, 37-42

Harada, H., Takahashi, Y., Kawakami, K., Ogura, T. and *Nakamura, H. Tracing retinal fiber trajectory with a method of transposon-mediated genomic integration in chick embryo. Dev. Growth Differ., 50, 697-702, 2008

*Takahashi, Y., (Review) Watanabe, T., Nakagawa, S., Kawakami, K. and Sato, Y. Transposon-mediated stable integration and tetracycline-inducible expression of electroporated transgenes in chicken embryos. “Methods in Avian Embryology” Methods in Cell Biology, 87, Edited by M. Bronner-Fraser, Elsevier Inc, 271-280, 2008

Sato, Y., Watanabe, T., Saito, D., Takahashi, T., Yoshida. S., Kohyama, J., Ohata, E., Okano, H. & *Takahashi., Y. Notch mediates the segmental specification of angioblasts in somites and their directed migration toward the dorsal aorta in avian embryos. Developmental Cell, 14, 890-901, 2008 (Nature Publishing Group “cellmigrationgateway”にてハイライト;doi:10.1038/cmg073)

*Takahashi, Y., and Sato, Y. (Review) Somitogenesis as a model to study the formation of morphological boundaries and cell epithelialization. Dev. Growth Differ., Suppl. 1, S149-55, 2008

2007年発表論文

Watanabe, T., Saito, D., Tanabe, K., Suetsugu, R., Nakaya, Y., Nakagawa, S. and *Takahashi, Y. Tet-on inducible system combined with in ovo electroporation dissects multiple roles of genes in somitogenesis of chicken embryos. Dev. Biol., 305, 625-636, 2007 (Faculty of 1000 Biologyによる推薦論文)

Sato, T., Kasai, T., Nakagawa, S., Tanabe, J., Watanabe, T., Kawakami, K., *Takahashi, Y. Stable integration and conditional expression of electroporated transgenes in chicken embryos. Dev. Biol., 305, 616-624, 2007(Faculty of 1000 Biologyによる推薦論文)

2006年発表論文

Tadokoro R., Sugio, M., Kutsuna, J., Tochinai, S. and Takahashi, Y. Early segregation of germ and somatic lineages during gonadal regeneration in the annelid, Enchytraeus japonensis. Current Biology 16(10) 1012-1017, 2006

Saito, D., Yonei-Tamura, S., Takahashi, Y. and Tamura, K. Level-specific role of paraxial mesoderm in regulation of Tbx5/Tbx4 expression and limb initiation. Developmental Biology 292, 79-89, 2006

Oka, Y., Sato, Y., Tsuda, H., Hanaoka, K., Hirai, Y. and Takahashi, Y. Epimorphin acts extracellularly to promote cell-sorting and aggregation during the condensation of vertebral cartilage. Developmental Biology 291, 25-37, 2006

Aoki, H., Hara, A., Nakagawa, S., Motohashi, T., Hirano, M., Takahashi, Y. and Kunisada, T. Embryonic stem cells that differentiate into RPE cell precursors in vitro develop into RPE cell monolayers in vivo. Exp. Eye Res. 82, 265-274, 2006

2005年発表論文

Sato, Y. and Takahashi, Y. A novel signal induces a segmentation fissure by acting in a ventral-to-dorsal direction in the presomitic mesoderm. Developmental Biology 282, 183-192, 2005

Takahashi, Y., Sato, Y., Suetsugu, R. and Nakaya Y. Mesenchymal-to-epithelial transition during somitic segmentation: A novel approach to study the roles of Rho family GTPases in morphogenesis. Cells Tissues Organs 179, 36-42, 2005

Takahashi, Y. Common mechanisms for boundary formation in somitogenesis and brain development :shaping up of the chic chick. Int. J. Dev. Biol. 9, 221-230, 2005