Wnt/b-catenin and estrogen signaling converge in vivo.Kouzmenko AP, Takeyama K, Ito S, Furutani T, Sawatsubashi S, Maki A, Suzuki E, Kawasaki Y, Akiyama T, Tabata T ,Kato SJ Biol Chem. 279: 40255 - 40258, 2004

研究内容概説ーWntと女性ホルモン(エストロゲン）の協調的な情報伝達系は様々な細胞種で検討されているものの、細胞内の直接的な相互作用分子は不明であった。本論文ではある種の大腸ガン細胞や乳ガン細胞でエストロゲンレセプター(ERα)とWntシグナルの下流と考えられるss-cateninが複合体形成することを、細胞および個体レベルで証明することに成功した。

2009年発表論文

Kim, M.S., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F. and Kato, S. DNA demethylation for hormone-induced transcriptional derepression. Nature, 2009, in press

Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato, S. GlcNAcylation of a histone methyltransferase in retinoic acid-induced granulopoiesis. Nature, 2009, in press

Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S. Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci USA 106, 3818-3822, 2009

2008年発表論文

Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A.P., Li, F., Tabata, T. and Kato, S. Co-repressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Mol Cell Biol 29, 1017-1034, 2008

Tanabe, M., Kouzmenko, AP., Ito, S., Sawatsubashi, S., Suzuki, E., Fujiyama, S., Yamagata, K., Zhao, Y., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Takeyama, K. and Kato, S. Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD. Genes Cells 13, 1279-1288, 2008

Murata, T., Suzuki, E., Ito, S., Sawatsubashi, S., Zhao, Y., Yamagata, K., Tanabe, M., Fujiyama, S., Kimura, S., Ueda, T., Matsukawa, H., Kouzmenko, A., Furutani, T., Kuranaga, E., Miura, M., Takeyama, K. and Kato, S. RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila. Biosci Biotechnol Biochem 72, 2255-2261, 2008

Kimura, S., Sawatsubashi, S., Ito, S., Kouzmenko, A., Suzuki, E., Zhao, Y., Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Yaegashi, N. and Kato, S. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Biochem Biophys Res Commun 371, 889-893, 2008

Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato, S. Switching of chromatin-remodelling complexes for oestrogen receptor-alpha. EMBO Rep 9, 563-568, 2008

Iriyama, A., Fujiki, R., Inoue, Y., Takahashi, H., Tamaki, Y., Takezawa, S., Takeyama, K., Jang, W.D., Kato, S. and Yanagi Y. A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor. J Biol Chem 283, 11947-11953, 2008

Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H.G., Krasnov, A., Georgieva, S.G., Schule, R., Takeyama, K., Kato, S., Tora, L. and Devys, D. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell 29, 92-101, 2008

Naito, A., Sato, T., Matsumoto, T., Takeyama, K., Yoshino, T., Kato, S. and Ohdera, M. Dihydrotestosterone inhibits murine hair growth via the androgen receptor. Br J Dermatol 159, 300-305, 2008

Kouzmenko, A.P., Takeyama, K., Kawasaki, Y., Akiyama, T. and Kato, S. Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli. Genes Cells 13,, 723-730, 2008

Kouzmenko, A.P., Takeyama, K., Kawasaki, Y., Akiyama, T. and Kato, S. Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli. Oncogene 27,, 4888-4899, 2008

2007年発表論文

Takada, I., Suzawa, M., Matsumoto, K. and Kato, S. Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci 1116, 182-195, 2007

Igarashi, M., Yogiashi, Y., Mihara, M., Takada, I., Kitagawa, H. and Kato, S. Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Mol Cell Biol 27, 7947-7954, 2007

Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M.Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K. and Kato, S. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol 9, 1273-1285, 2007

Arai, M. A., Takeyama, K., Ito, S., Kato, S., Chen, T.C. and Kittaka, A. High-throughput system for analyzing ligand-induced cofactor recruitment by vitamin D receptor. Bioconjug Chem 18, 614-620, 2007

Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A.P., Nohara, K., Chiba, T., Fujii-Kuriyama, Y. and Kato, S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446, 562-566, 2007

Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K. and Kato, S. Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure. Trends Endocrinol Metab 18, 183-189, 2007

Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B.W. and Kato, S. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol 9, 604-611, 2007

Memezawa, A., Takada, I., Takeyama, K., Igarashi, M., Ito, S., Aiba, S., Kato, S. and Kouzmenko, A.P. Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes. Oncogene 26, 5038-5045, 2007

Takezawa, S., Yokoyama, A., Okada, M., Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H. and Kato, S. A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function. EMBO J 26, 764-774, 2007

Kim, M.S., Fujiki, R., Murayama, A., Kitagawa, H., Yamaoka, K., Yamamoto, Y., Mihara, M., Takeyama, K. and Kato, S. 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter. Mol Endocrinol 21, 334-342, 2007

Miyamoto, J., Matsumoto, T., Shiina, H., Inoue, K., Takada, I., Ito, S., Itoh, J., Minematsu, T., Sato, T., Yanase, T., Nawata, H., Osamura, Y.R. and Kato, S. The pituitary function of androgen receptor constitutes a glucocorticoid production circuit. Mol Cell Biol 27, 4807-4814, 2007

2006年発表論文

Yamaoka, K., Kim, M., Takada, I., Takeyama, K., Kamimura, T. and Kato, S. Culture serum-induced conversion from agonist to antagonist of a Vitamin D analog, TEI-9647. J Steroid Biochem Mol Biol 100, 177-183, 2006

Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H. and Kato, S. Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci USA 103, 224-229, 2006

Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J. and Kato, S. An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification. J Biol Chem 281, 20-26, 2006

2005年発表論文

T. Matsumoto, K. Takeyama, T. Sato, S. Kato. Study of androgen receptor functions by genetic models. J. Biochem. 138, 105-110, 2005

Y. Masuhiro, Y. Mezaki, M. Sakari, K. Takeyama, T. Yoshida, K. Inoue, J. Yanagisawa, S. Hanazawa, W. O'Malley B, S. Kato. Splicing potentiation by growth factor signals via estrogen receptor phosphorylation. Proc. Natl. Acad. Sci. U S A 102, 8126-8131, 2005

T. Furutani, K. Takeyama, M. Tanabe, H. Koutoku, S. Ito, N. Taniguchi, E. Suzuki, M. Kudoh, M. Shibasaki, H. Shikama, S. Kato. Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target. J. Pharmacol. Exp. Ther. 315, 545-552, 2005

T. Furutani, K. Takeyama, H. Koutoku, S. Ito, N. Taniguchi, E. Suzuki, M. Kudoh, M. Shibasaki, H. Shikama, S. Kato. A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line. Biosci. Biotechnol. Biochem. 69, 2236-2239, 2005

Takada, I., Suzawa M. and Kato, S. Nuclear receptors as targets for drug development: Crosstalk between peroxisome proliferator-activated receptor γ and cytokines in bone marrow-derived mesenchymal stem cells. J Pharamcol Sci 97, 184-189, 2005

Unno, A., Takada, I., Takezawa, S., Oishi, H., Baba, A., Shimizu, T., Tokita, A., Yanagisawa, J. and Kato, S. TRRAP as a hepatic coactivator of LXR and FXR function. Biochem Biophys Res Commun 327, 933-938, 2005

2004年発表論文

K. Takeyama, S. Ito, S. Sawatsubashi, Y. Shirode, A. Yamamoto, E. Suzuki, A. Maki, K. Yamagata, Y. Zhao, A. Kouzmenko, T. Tabata, S. Kato. A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Biosci. Biotechnol. Biochem. 68, 1209-1215, 2004

S. Sawatsubashi, A. Maki, S. Ito, Y. Shirode, E. Suzuki, Y. Zhao, K. Yamagata, A. Kouzmenko, K. Takeyama, S. Kato. Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation. Biochem. Biophys. Res. Commun. 320, 268-272, 2004

A. Murayama, M.S. Kim, J. Yanagisawa, K. Takeyama, S. Kato. Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J. 23, 1598-1608, 2004

A. Maki, S. Sawatsubashi, S. Ito, Y. Shirode, E. Suzuki, Y. Zhao, K. Yamagata, A. Kouzmenko, K. Takeyama, S. Kato. Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers. Biochem. Biophys. Res. Commun. 320, 262-267, 2004

A.P. Kouzmenko, K. Takeyama, S. Ito, T. Furutani, S. Sawatsubashi, A. Maki, E. Suzuki, Y. Kawasaki, T. Akiyama, T. Tabata, S. Kato. Wnt/beta-catenin and estrogen signaling converge in vivo. J. Biol. Chem. 279, 40255-40258, 2004

S. Kato, T. Matsumoto, H. Kawano, T. Sato, K. Takeyama. Function of androgen receptor in gene regulations. J. Steroid Biochem. Mol. Biol. 89-90, 627-633, 2004

S. Ito, K. Takeyama, A. Yamamoto, S. Sawatsubashi, Y. Shirode, A. Kouzmenko, T. Tabata, S. Kato. In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation. Genes Cells 9, 983-992, 2004