文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

塚原 伸治 TSUKAHARA, Sinji
国立環境研究所 環境リスク研究センター
研究項目A02 「脳の性分化と行動の解析」
研究課題 視床下部における生殖中枢の性差と性分化機構の解明

2009年発表論文

Tsukahara S. Sex differences and roles of sex steroids in apoptosis of sexually dimorphic nuclei of preoptic area in postnatal rats. Journal of Neuroendocrinology, 21, 370-376, 2009

2008年発表論文

Tsukahara S. Hojo R, Kuroda Y, & Fujimaki H: Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats. Neuroscience Letters, 432, 58-63, 2008

2006年発表論文

Fumihiko Maekawa, Ken Fujiwara, Shinji Tsukahara and Toshihiko Yada. Pituitary adenylate cyclase-activating polypeptide neurons of the ventromedial hypothalamus project to the midbrain central gray. Neuroreport, 17, 221-224, 2006

Shinji Tsukahara, Masaki Kakeyama and Yuki Toyofuku. Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats. J. Neurobiol. 2006, in press

Sohel Ahmed, Tin-Tin-Win-Shwe, Shoji Yamamoto, Shinji Tsukahara, Naoki Kunugita, Keiichi Arashidani and Hidekazu Fujimaki. Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposure. Neurotoxicology 2006, in press

Shinji Tsukahara, Shoji Yamamoto, Tin-Tin-Win-Shwe, Sohel Ahmed, Naoki Kunugita, Keiichi Arashidani and Hidekazu Fujimaki. Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized mice. Neuroimmunomodulation 2006, in press

Shinji Tsukahara. Increased Fos immunoreactivity in suprachiasmatic nucleus before luteinizing hormone surge in estrogen-treated ovariectomized female rats. Neuroendocrinology 2006, in press

2005年発表論文

Tsukahara S, Tanaka S, Ishida K, Hoshi N & Kitagawa H. Age-related change and its sex differences in histoarchitecture of the hypothalamic suprachiasmatic nucleus of F344/N rats. Experimental Gerontology,40, 147-155, 2005.

2004年発表論文

Maekawa F, Tsukahara S, Tanaka K & Ohki-Hamazaki H. Distributions of two chicken bombesin receptors, bombesin receptor subtype-3.5 (chBRS-3.5) and gastrin-releasing peptide receptor (chGRP-R) mRNAS in the chicken telencephalon. Neuroscience, 125, 569-582, 2004.

Tsukahara S, Inami K, Maekawa F, Kakeyama M, Yokoyama T, Yuji M, Kitagawa H, Kannan Y & Yamanouchi K: Postnatal apoptosis, development, and sex difference in the lateral septum of rats. Journal of Comparative Neurology, 475, 177-187, 2004.