文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

柳川 右千夫 YANAGAWA, Yuchio
群馬大学 大学院医学系研究科
研究項目A02 「脳の性分化と行動の解析」
研究課題 性行動と母性行動の発達における神経伝達物質、GABAの役割(平成17年度〜平成18年度)
     性行動と母性行動の発達における神経伝達物質、GABAの役割、パート2(平成19年度〜平成20年度)

2009年発表論文

Kubo, K., Nishikawa, K., Yamada, M.H., Ishizeki, J., Yanagawa, Y., & Saito, S. Altered responses to propofol, but not ketamine, in mice deficient in the 65-kDa isoform of glutamate decarboxylase. J. Pharmacol. Exp. Ther.  in press

Pan, B.-X., Dong, Y., Ito, W., Yanagawa, Y., Shigemoto, R., & Morozov, A. Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron 61  , 917-929, 2009

2008年発表論文

Kaneko, K., Tamamaki, N., Owada, H., Kakizaki, T., Kume, N., Totsuka, M., Yamamoto, T., Yawo, H., Yagi, T., Obata, K., & Yanagawa, Y. Noradrenergic excitation of a subpopulation of GABAergic cells in the basolateral amygdala via both activation of nonselective cationic conductance and suppression of resting K+ conductance: A study using glutamate decarboxylase 67-green fluorescent protein knock-in mice. Neuroscience 157  , 781-797, 2008

Brown, R.E., McKenna, J.T., Winston, S., Basheer, R., Yanagawa, Y., Thakkar, M.M., & McCarley, R.W. Characterization of GABAergic neurons in rapid-eye-movement (REM) sleep controlling regions of the brainstem reticular formation in GAD67-GFP knock-in mice. Eur. J. Neurosci. 27  , 352-363, 2008

Bian, X., Yanagawa, Y., Chen, W.R., & Luo, M. Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala. J. Neurophysiol. 99  , 77-86, 2008

Uematsu, M., Hirai, Y., Karube, F., Ebihara, S., Kato, M., Abe, K., Obata, K., Yoshida, S. Hirabayashi, M., Yanagawa, Y. & Kawaguchi, Y. Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats. Cereb. Cortex 18  , 315-330, 2008

2007年発表論文

Labouebe, G., Lomazzi, M., Cruz H.G., Creton, C., Lujan, R., Li, M., Yanagawa. Y., Obata, K., Watanabe, M., Wickman, K., Boyer, S.B., Slesinger, P.A., & Luscher, C. RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.  Nat. Neurosci. 10  , 1559-1568, 2007

Berghuis, P., Rajnicek, A.M., Morozov, Y.M., Ross, R.A., Mulder, J., Urban, G.M., Monory, K., Marsicano, G., Matteoli, M., Canty, A., Irving, A.J., Katona, I., Yanagawa, Y., Rakic, P., Lutz, B., Mackie, K., & Harkany T. Hardwiring the brain: Endocannabinoids shape neuronal connectivity. Science 316  , 1212-1216, 2007

Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T.K., & Yamakawa, K. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27  , 5903-5914, 2007

Fujii, M., Arata, A., Kanbara-Kume, N., Saito, K., Yanagawa, Y., & Obata, K. Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. Neuroscience, 146  , 1044-52, 2007

Panzanelli, P., Fritchy, J.M., Yanagawa, Y., Obata, K., & Sassoe-Pognetto, M. GABAergic phenotype of periglomerular cells in the rodent olfactory bulb. J. Comp. Neurol. 502  , 990-1002, 2007

Hoskison, M.M., Yanagawa, Y., Obata, K & Shuttleworth, W.C. Calcium-dependent NMDA-induced dendric injury and MAP2 loss in acute hippocampal slices. Neuroscience, 145  , 66-79, 2007

May, C.A., Nakamura, K., Fujiyama, F., Komatsu, Y., & Yanagawa, Y. Homozygous GAD65 and heterozygous GAD67 knock-out mice reveal normal retinal development and maintenance despite reduced amounts of GABA. Acta Neuropathologica, 113  , 101-103, 2007

2006年発表論文

Jiao, Y., Zhang, C., Yanagawa, Y. & Sun, Q.-Q. Major effects of sensory experiences on the neocortical inhibitory circuits. J. Neurosci. 26  , 8691-8701, 2006

Shun-ichi Kuwana, Naoko Tsunekawa, Yuchio Yanagawa, Yasumasa Okada, Junya Kuribayashi and Kunihiko Obata. Electrophysiological and morphological characteristics of GABAergic respiratory neurons in the mouse pre-Boetzinger complex. Eur. J. Neurosci. 23, 667-674, 2006

Masahiko Tanaka, Yuchio Yanagawa, Kunihiko Obata and Tohru Marunouchi. Dendritic morphogenesis of cerebellar Purkinje cells through extension and retraction revealed by long-term tracking of living cells in vitro. Neuroscience, in press

2005年発表論文

Araki, L.*, Sakagami, H.*, Yanagawa, Y.* (*equal contribution, co-first author), Hikima, T., Ishizuka, T. and Yawo, H. Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex.Genesis 42, 53-60, 2005

Abe, H., Yanagawa, Y., Kanbara, K., Maemura, K., Hayasaki, H., Azuma, H., Obata, K., Katsuoka, Y., and Watanabe, M. Epithelial localization of green fluorescent protein-positive cells in epididymis of the GAD67-GFP knock-in mous. J. Andrology, 2005 in press