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y2015”Nz
Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis.
Yuichi Shima, Sawako Matsuzaki, Kanako Miyabayashi, Hiroyuki Otake, Takashi Baba, Shigeaki Kato, Ilpo Huhtaniemi, and Ken-ichirou Morohashi.
Mol Endocrinol. 29, 1581-1593, 2015
Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.
Megumi Tsuchiya, Shin Isogai, Hiroaki Taniguchi, Hidehito Tochio, Masahiro Shirakawa, Ken-ichirou Morohashi, Yasushi Hiraoka, Tokuko Haraguchi, and Hidesato Ogawa.
Sci Rep. 5, 14498, 2015
Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of SOX9.
Yuko Katoh-Fukui, Maki Igarashi, Keisuke Nagasaki, Reiko Horikawa, Toshiro Nagai, Takayoshi Tsuchiya, Erina Suzuki, Mami Miyado, Kenichiro Hata, Kazuhiko Nakabayashi, Keiko Hayashi, Yoichi Matsubara, Takashi Baba, Ken-ichirou Morohashi, Arisa Igarashi, Tsutomu Ogata, Shuji Takada, and Maki Fukami.
Mol Genet Genomic Med. 3, 550-557, 2015
Heterogeneity of ovarian theca and interstitial gland cells in mice.
Kanako Miyabayashi, Kaori Tokunaga, Hiroyuki Otake, Takashi Baba, Yuichi Shima and Ken-ichirou Morohashi.
PLoS One 3, e0128352, 2015

y2014”Nz
Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
Atsushi Yokoyama, Katsuhide Igarashi, Tetsuya Sato, Kiyoshi Takagi, Yurina Shishido, Takashi Baba, Ryo Ito, Jun Kanno, Yasuyuki Ohkawa, Ken-ichirou Morohashi and Akira Sugawara.
J Biol Chem 289, 18152-18162, doi:10.1074/jbc.M114.566448, 2014

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung & Ken-Ichirou Morohashi.
Nature Communications 5, 3634, doi:10.1038/ncomms4634, 2014

y2013”Nz
Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
Yuka Fujimoto, Satomi S. Tanaka, Yasuka L. Yamaguchi, Hiroki Kobayashi, Shunsuke Kuroki, Makoto Tachibana, Mai Shinomura, Yoshiakira Kanai,@Ken-ichirou Morohashi, Kiyoshi Kawakami, and Ryuichi Nishinakamura.
Dev Cell 26, 416-430, 2013

Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries.
Kyoko Harikae, Kento Miura, Mai Shinomura, Shogo Matoba, Ryuji Hiramatsu, Naoki Tsunekawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Ken-ichirou Morohashi, and Yoshiakira Kanai.
J Cell Sci 126, 2834-2844, 2013

Steroid hormones and the Development of reproductive organs.
Ken-ichirou Morohashi, Takashi Baba, Minoru Tanaka
Sexual Development 7, 61-79, 2013

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes.
Yuichi Shima, Kanako Miyabayashi, Shogo Haraguchi, Tatsuhiko Arakawa, Hiroyuki Otake, Takashi Baba, Sawako Matsuzaki, Yurina Shishido, Haruhiko Akiyama, Taro Tachibana, Kazuyoshi Tsutsui, Ken-ichirou Morohashi
Mol Endocrinol. 27, 63-73, 2013

Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells.
Kanako Miyabayashi, Yuko Katoh-Fukui, Hidesato Ogawa, Takashi Baba, Yuichi Shima, Noriyuki Sugiyama, Kunio Kitamura, Ken-ichirou Morohashi
PLOS One 8, e68050, 2013

y2012”Nz
Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development.
Mami Miyado, Michiko Nakamura, Kenji Miyado, Ken-ichirou Morohashi, Shinichiro Sano, Eiko Nagata, Maki Fukami, and Tsutomu Ogata
Endocrinology 153, 6033-6040, 2012

WNT family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbesterol exposure in mice.
Takeshi Nakamura, Shinichi Miyagawa, Yoshinao Katsu, Hajime Watanabe, Takeshi Mizutani, Tomomi Sato, Ken-ichirou Morohashi, Takashi Takeuchi, Taisen Iguchi
Toxicology 296, 13-19, 2012

Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Yuko Katoh-Fukui, Kanako Miyabayashi, Tomoko Komatsu, Akiko Owaki, Takashi Baba, Yuichi Shima, Tomohide Kidokoro, Yoshiakira Kanai, Andreas Schedl, Dagmar Wilhelm, Peter Koopman, Yasushi Okuno, Ken-ichirou Morohashi
Endocrinology 153, 913-924, 2012

Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal Leydig cells.
Yuichi Shima, Kanako Miyabayashi, Takashi Baba, Hiroyuki Otake, Sanae Oka, Mohamad Zubair, Ken-ichirou Morohashi
Endocrinology 153, 417-425, 2012

SF-1 expression during adrenal development and tumorigenesis.
Gardiner JR, Y Shima, Ken-ichirou Morohashi, Amanda Swain
Mol. Cell. Endocrinol. 351, 12-18, 2012 Review

y2011”Nz
DNA Methylation of Intronic Enhancers Directs Tissue-Specific Expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP).
Erling A. Hoivik, Trine E. Bjanesoy, Oliver Mai, Shiki Okamoto, Yasuhiko Minokoshi, Yuichi Shima, Ken-ichirou Morohashi, Ulrich Boehm, and Marit Bakke
Endocrinology 152, 2100-2112, 2011

The fetal and adult adrenal cortex
Ken-ichirou Morohashi and Mohamad Zubair
Mol. Cell. Endocrinol. 336, 193-197, 2011, Review

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