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y2020”Nz
GC-MS-based metabolic signatures reveal comparative steroidogenic pathways between fetal and adult mouse testes.
Soyun Han, Takashi Baba, Shogo Yanai, Dong Jun Byun, Ken-Ichirou Morohashi, Jae-Hong Kim, Man Ho Choi.
Andrology. 9(1), 400-406, doi:10.1111/andr.12893., 2020
Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice.
Hiroki Yamazaki, Mayu Nishimura, Masaaki Uehara, Akiko Kuribara-Souta, Motohisa Yamamoto, Noritada Yoshikawa, Ken-Ichirou Morohashi, Hirotoshi Tanaka.
Am J Physiol Endocrinol Metab.doi:10.1152/ajpendo.00184.2020., 2020, Online ahead of print.
Coordination of Multiple Cellular Processes by NR5A1/Nr5a1.(Review)
Ken-Ichirou Morohashi, Miki Inoue, Takashi Baba.
Endocrinol Metab (Seoul). 35(4), 756-764, doi:10.3803/EnM.2020.402., 2020

y2019”Nz
Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody.
Chikako Yokoyama, Yuta Chigi, Takashi Baba, Atsushi Ohshitanai, Yumi Harada, Fumiya Takahashi, Ken-Ichirou Morohashi.
Biochem Biophys Res Commun. 511(4), 916-920, doi:10.1016/j.bbrc.2019.02.100., 2019
Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.
Yuko Katoh-Fukui, Takashi Baba, Tetsuya Sato, Hiroyuki Otake, Yuko Nagakui-Noguchi, Miyuki Shindo, Mikita Suyama, Yasuyuki Ohkawa, Hideki Tsumura, Ken-Ichirou Morohashi, Maki Fukami.
Bone. 120, 219-231, doi:10.1016/j.bone.2018.10.021., 2019
y2018”Nz
Adrenocortical development: Lessons from mouse models.
Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaelle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Veronique Ducros, Anne-Marie Lefrancois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-Ichirou Morohashi, David T Breault, Pierre Val, Antoine Martinez.
Ann Endocrinol. (Paris) 79, 95-97, doi: 10.1016/j.ando.2018.03.014, 2018
Recent progress in understanding the mechanisms of Leydig cell differentiation. (Review)
Miki Inoue, Takashi Baba, and Ken-ichirou Morohashi.
Mol Cell Endocrinol. 2018. in press
PKA signalling drives zonal conversion within adult adrenocortical lineage in a sexually dimorphic manner.
Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaelle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Veronique Ducros, Anne-Marie Lefrancois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-ichirou Morohashi, David Breault, Pierre Val, Antoine Martinez.
JCI insight. 3(2), e98394, doi:10.1172/jci.insight.98394, 2018
Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Y. Ishihara, J-Y. Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, L. Wang, R. Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man-Ho Choi, Yasuyuki Ohkawa, Ken-ichirou Morohashi.
Communications Biology. 1, 18, DOI: 10.1038/s42003-018-0020-z, 2018

y2017”Nz
Timing of adrenal regression by synergistic interaction between Sf1 SUMOylation and Dax1.
Yewei Xing, Ken-ichirou Morohashi, Holley A. Ingraham, and Gary D. Hammer.
Development. 144, 3798-3807, 2017
Leydig progenitor cells in fetal testis. (Review)
Yuichi Shima, Ken-ichirou Morohashi.
Mol Cell Endocrinol. 445, 55-64, 2017
Lysosomal activity maintains Ad4BP/SF-1 protein stability for proper steroidogenic cell growth.
Jhih-Siang Syu, Takashi Baba, Jyun-Yan Huang, Hidesato Ogawa, Chi-Han Hsieh, Jin-Xian Hu, Ting-Yu Chen, Tzu-Chien Lin, Ken-Ichirou Morohashi, Bu-Miin Huang, Fu-I Lu, and Chia-Yih Wang.
Scientific Report. 7, 240, 2017
Role of Ad4BP/SF-1 in regulating NADPH production in Y-1 cells.
Bing Li, Takashi Baba, Kanako Miyabayashi, Tetsuya Sato, Yuichi Shima, Daisuke Miura, Yasuyuki Ohkawa, Mikita Suyama, and Ken-ichirou Morohashi.
Endocrine J. 64, 315-324, 2017
Alterations in fetal Leydig cell gene expression during fetal and adult development.
Kanako Miyabayashi, Yuichi Shima, Miki Inoue, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Mikita Suyama, Ken-ichirou Morohashi.
Sexual Development. 11, 53-63, 2017
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.
Yurina Shishido, Takashi Baba, Tetsuya Sato, Yuichi Shima, Kanako Miyabayashi, Miki Inoue, Haruhiko Akiyama, Hiroshi Kimura, Yoshiakira Kanai, Yasuhiro Ishihara, Shogo Haraguchi, Akira Miyazaki, Damjana Rozman, Takeshi Yamazaki, Man-Ho Choi, Yasuyuki Ohkawa, Mikita Suyama, Ken-ichirou Morohashi.
Scientific Rep. 7, 41912, 2017
Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues.
Maki Igarashi, Kei Takasawa, Akiko Hakoda, Junko Kanno, Shuji Takada, Mami Miyado, Takashi Baba, Ken-ichirou Morohashi, Toshihiro Tajima, Kenichiro Hata, Kazuhiko Nakabayashi, Yoichi Matsubara, Ryohei Sekido, Tsutomu Ogata, Kenichi Kashimada, and Maki Fukami.
Hum Mutat. 38, 39-42, 2017
Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development.
Kanako Miyabayashi, Yuichi Shima, Miki Inoue, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Mikita Suyama, and Ken-ichirou Morohashi.
Sex Dev. 11, 53-63, 2017
Leydig progenitor cells in fetal testis.
Yuichi Shima and Ken-ichirou Morohashi.
Mol Cell Endocrinol. 445, 55-64, 2017

y2016”Nz
Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.
Takashi Umehara, Ikko Kawashima, Tomoko Kawai, Yumi Hoshino, Ken-ichirou Morohashi, Yuichi Shima, Wenxian Zeng, JoAnne S. Richards, and Masayuki Shimada.
Endocrinology 157, 4899-4913, 2016
SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1.
Megumi Hatano, Toshiro Migita, Tomokazu Ohishi, Yuichi Shima, Yoshihiro Ogawa, Ken-Ichirou Morohashi, Yukihiro Hasegawa, and Futoshi Shibasaki.
Endocrine. 54, 484-496, 2016
Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Miki Inoue, Yuichi Shima, Kanako Miyabayashi, Kaori Tokunaga, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Haruhiko Akiyama, Mikita Suyama, and Ken-ichirou Morohashi.
Endocrinology 157, 1222-1233, 2016

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