Department of Virology,Faculty of Medicine,Kyushu University


Kubota M, Takeuchi K, Watanabe S, Ohno S, Matsuoka R, Kohda D, Nakakita S, Hiramatsu H, Suzuki Y, Nakayama T, Terada T, Shimizu K, Shimizu N, Shiroishi M, Yanagi Y, Hashiguchi T (2016). Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus. Proc Natl Acad Sci USA. 113:11579-11584

Shirogane Y, Watanabe S, Yanagi Y. (2016) Cooperative Interaction Within RNA Virus Mutant Spectra. Curr Top Microbiol Immunol. 392:219-229.

Hikita SI, Yanagi Y, Ohno S. (2015) Murine gammaherpesvirus 68 open reading frame 35 is required for efficient lytic replication and latency. J Gen Virol. 96:3624–3634.

Koga R, Sugita Y, Noda T, Yanagi Y, Ohno S. (2015) Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region. J Virol. 89:10524-10531.

Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO (2015) Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody. Cell. 160: 904-912.

Watanabe S, Ohno S, Shirogane Y, Suzuki OS, Koga R, Yanagi Y (2015) Measles Virus Mutants Possessing the Fusion Protein with Enhanced Fusion Activity Spread Effectively in Neuronal Cells, but Not in Other Cells, without Causing Strong Cytopathology. J Virol 89: 2710-2717.

Ichinohe T, Yamazaki T, Koshiba T, Yanagi Y. (2013) Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc Natl Acad Sci U S A. 110:17963-17968

Ito M, Iwasaki M, Takeda M, Nakamura T, Yanagi Y, Ohno S.(2013) Measles Virus Nonstructural C Protein Modulates Viral RNA Polymerase Activity by Interacting with Host Protein SHCBP1. J Virol.87:9633-962.

Shirogane Y, Watanabe S, Yanagi Y. (2013) Cooperation: another mechanism of viral evolution. Trends Microbiol. 21:320-324

Tahara M, Ohno S, Sakai K, Ito Y, Fukuhara H, Komase K, Brindley MA, Rota PA, Plemper RK, Maenaka K, Takeda M. (2013) The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope J Virol.87:3583-3586.

Nakatsu Y, Ma X, Seki F, Suzuki T, Iwasaki M, Yanagi Y, Komase K, Takeda M. (2013)Intracellular transport of the measles virus RNP complex is mediated by Rab11A-positive recycling endosomes and drives virus release from the apical membrane of polarized epithelial cells. J Virol. 87:4683-4693

Nakashima M, Shirogane Y, Hashiguchi T, Yanagi Y. (2013) Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. J Biol Chem.288:8085-8091

Watanabe S, Shirogane Y, Suzuki SO, Ikegame S, Koga R, Yanagi Y. (2013) Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.J Virol. 87(5):2648-59

Shirogane Y, Watanabe S, Yanagi Y. (2012) Cooperation between different RNA virus genomes produces a new phenotype.Nat Commun.3:1235.

Maenaka K, Hashiguchi T, Yanagi Y. (2012) Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination (Review. Japanese)Nihon Rinsho.70(4):695-703

Ito M, Yanagi Y, Ichinohe T. (2012) Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome. PLoS Pathog. 8(8):e1002857.

Mitsuki YY, Terahara K, Shibusawa K, Yamamoto T, Tsuchiya T, Mizukoshi F, Ishige M, Okada S, Kobayashi K, Morikawa Y, Nakayama T, Takeda M, Yanagi Y, Tsunetsugu-Yokota Y.(2012) HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4+ T cells.J Virol. 86(13):7227-34.

Harada Y, Tanaka S, Motomura Y, Harada Y, Ohno S, Ohno S, Yanagi Y, Inoue H, Kubo M.(2012) The 3' Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells.Immunity. 36(2):188-200

Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y. (2012) Crystallization Strategy for the Glycoprotein-receptor Complex Between Measles Virus Hemagglutinin and its Cellular Receptor SLAMProtein Pept Lett. 19(4):468-73.

Komune N, Ohashi M, Matsumoto N, Kimitsuki T, Komune S, Yanagi Y.(2012) No evidence for an association between persistent measles virus infection and otosclerosis among patients with otosclerosis in Japan.J Clin Microbiol. 50:626-32.

Komune N, Ichinohe T, Ito M, Yanagi Y. (2011) Measles virus V protein inhibits NLRP3 inflammasome-mediated IL-1 beta secretion.J Virol. 85:13019-26.

Hashiguchi T, Maenaka K, Yanagi Y.(2011) Measles virus hemagglutinin: structural insights into cell entry and measles vaccine.Front Microbiol. 2:247.

Seki F, Yamada K, Nakatsu Y, Okamura K, Yanagi Y, Nakayama T, Komase K, Takeda M.(2011) The SI Strain of Measles Virus Derived From an SSPE Patient Possesses Typical Genome Alterations and Unique Amino Acid Changes that Modulate Receptor Specificity and Reduce Membrane Fusion Activity.J Virol. 85:11871-82.

Iwasaki M, Yanagi Y.(2011) Expression of the Sendai (murine parainfluenza) virus C protein alleviates restriction of measles virus growth in mouse cells.Proc Natl Acad Sci U S A. 108:15384-9.

Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y. (2011) Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol. 18:135-41.

Koshiba T, Yasukawa K, Yanagi Y, Kawabata S. (2011) Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling. Sci Signal. 4(158):ra7.

Shirogane Y, Takeda M, Tahara M, Ikegame S, Nakamura T, Yanagi Y. (2010) Epithelial-mesenchymal transition abolishes the susceptibility of polarized epithelial cell lines to measles virus. J Biol Chem. 285:20882-90.

Koga R, Ohno S, Ikegame S, Yanagi Y. (2010) Measles virus-induced immunosuppression in SLAM knock-in mice. J Virol. 84:5360-7.

Meng X, Nakamura T, Okazaki T, Inoue H, Takahashi A, Miyamoto S, Sakaguchi G, Eto M, Naito S, Takeda M, Yanagi Y, Tani K. (2010) Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild-type N, P, L genes on human renal cell carcinoma. Mol Ther. 18:544-51.

Ikegame S, Takeda M, Ohno S, Nakatsu Y, Nakanishi Y, Yanagi Y. (2010) Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells. J Virol. 84: 372-9

Nakatsu Y, Takeda M, Iwasaki M, Yanagi Y. (2009) A Highly Attenuated Measles Virus Vaccine Strain Encodes a Fully Functional C Protein. J Virol. 83: 11996-2001.

Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T.(2009) Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling.Sci Signal. 2: ra47.

Iwasaki M, Takeda M, Shirogane Y, Nakatsu Y, Nakamura T, Yanagi Y. (2009) The Matrix Protein of Measles Virus Regulates Viral RNA Synthesis and Assembly by Interacting with the Nucleocapsid Protein.J Virol. 83: 10374-83.

Yanagi, Y., Hashiguchi, T., and Takeda, M. (2008) Recent progress in measles virus research (review, Japanese). The Journal of Pediatric Infectious Diseases and Immunology.20, 479-483.

Yanagi, Y., Takeda, M., Ohno, S., and Hashiguchi, T. Measles virus receptors. Griffin, D. E. and Oldstone, M. B. A. ed. Current Topics in Microbiology and Immunology 329. Measles history and basic biology. Springer. 13-30, 2009 (review)

Takeda, M., Hashiguchi, T., and Yanagi, Y. (2008) Measles virus receptors and pathogenesis (review, Japanese). Experimental Medicine.26, 2891-6.

Takeda, M., Ohno, S., Tahara, M., Takeuchi, H., Shirogane, Y., Ohmura, H., Nakamura, T., and Yanagi, Y.(2008)Measles virus possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM-knockin mice.J Virol. 82,11979-84.

Nakatsu, Y., Takeda, M., Ohno, S., Shirogane, Y., Iwasaki, M., and Yanagi, Y.(2008)Measles virus circumvents the host interferon response by different actions of the C and V proteins.J Virol . 82. 8296-306.

Shirogane, Y., Takeda, M., Iwasaki, M., Ishiguro, N., Takeuchi, H., Nakatsu, Y., Tahara, M., Kikuta, H., and Yanagi, Y. (2008)Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2. J Virol . 82. 8942-6.

Hashiguchi, T., Maenaka, K., and Yanagi, Y. (2008) X-ray crystallographic analysis of measles virus hemagglutinin (review, Japanese). Uirusu . 58. 1-10.

Takeda, M. (2008) Measles virus breaks through epithelial cell barriers to achieve transmission. (review) J Clin Invest . 118, 2386-9.

Tahara, M., Takeda, M., Shirogane, Y., Hashiguchi, T., Ohno, S., and Yanagi, Y. (2008)Measles virus infects both polarized epithelial and immune cells using distinctive receptor-binding sites on its hemagglutinin. J Virol . 82, 4630-7.

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Sasaki, K., Kohda, D., Yanagi, Y., and Maenaka, K. (2008)Homogeneous sugar modification improves crystallization of measles virus hemagglutinin. J Virol Methods . 149, 171-4.

Navaratnarajah, C. K., Vongpunsawad, S., Oezguen, N., Stehle, T., Braun, W., Hashiguchi, T., Maenaka, K., Yanagi, Y., and Cattaneo, R. (2008)Dynamic interaction of the measles virus hemagglutinin with its receptor SLAM. J Biol Chem . 283, 11763-71.

Takeda, M., and Yanagi, Y. (2008) Current topics of measles virus: Crystal structure of the receptor-binding H protein and a putative receptor involved in infection of polarized epithelial cells. (review, Japanese) Clinical Microbiology. 35 , 11-15.

de Swart, R. L., Ludlow, M., de Witte, L., Yanagi, Y., van Amerongen, G., McQuaid, S., Yuksel, S., Geijtenbeek, T. B., Duprex, W. P., and Osterhaus, A. D. (2007) Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLoS Pathog. 3 , e178.

Hashiguchi, T., Kajikawa, M., Maita, N., Takeda, M., Kuroki, K., Sasaki, K., Kohda, D., Yanagi, Y., and Maenaka, K.(2007) Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proc Natl Acad Sci U S A. 104. 19535-40

Takeda, M., Tahara, M., Hashiguchi, T., Sato, T. A., Jinnouchi, F., Ueki, S., Ohno, S., and Yanagi, Y.(2007) A Human Lung Carcinoma Cell Line Supports Efficient Measles Virus Growth and Syncytium Formation via SLAM- and CD46-Independent Mechanism. J Virol.81. 12091-12096.

Yanagi, Y and Takeda, M (2007) Virus entry and receptors. (review, Japanese) Japanese Scientific Monthly. 60. 199-202.

Yanagi, Y, Takeda, M and Ohno, S (2007) Measles virus entry and receptors. (review, Japanese) Protein, Nucleic Acid, and Enzyme. 52. 1088-1094.

Tahara, M, Takeda, M, and Yanagi, Y. (2007) Altered interaction of the matrix protein with the cytoplasmic tail of hemagglutinin modulates measles virus growth by affecting virus assembly and cell-cell fusion. J Virol. 81. 6827-36.

Tahara, M., Takeda, M., Seki, F., Hashiguchi, T., and Yanagi, Y. (2007) Multiple amino acid substitutions in hemagglutinin are necessary for wild-type measles virus to acquire the ability to use receptor CD46 efficiently. J Virol. 81. 2564-72

Ohno, S., Ono, N., Seki, F., Takeda, M., Kura, S., Tsuzuki, T., and Yanagi, Y. (2007) Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. J Virol. 81 . 1650-9.

McCausland, M. M., Yusuf, I., Tran, H., Ono, N., Yanagi, Y., and Crotty, S. (2007) SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol. 178. 817-28.

Yanagi, Y, Takeda, M, and Ohno, S. (2006) Measles virus: cellular receptors, tropism and pathogenesis. J Gen Virol. 87. 2767-79. Review.

Nakatsu, Y., Takeda, M., Ohno, S., Koga, R., and Yanagi, Y. (2006) Translational inhibition and increased interferon induction in cells infected with a C protein-deficient measles virus. J Virol. 80. 11861-11867.

Nakatsu, Y., Takeda, M., Kidokoro, M., Kohara, M., and Yanagi, Y. (2006) Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain. J Virol Methods. 137 . 152-155.

Takeda, M., and Yanagi, Y. (2006) Reverse genetics for measles virus. (review, Japanese) Fukuoka Igaku Zasshi. 97 . 140-145.

Yanagi, Y. Takeda, M., Ohno, S., and Seki, F. (2006) Measles virus receptors and tropism (review). Jpn J Infect Dis . 59 . 1-5.

Takeda, M., Nakatsu, Y., Ohno, S., Seki, F., Tahara, M., Hashiguchi, T., and Yanagi, Y. (2006) Generation of measles virus with a segmented RNA genome. J Virol. 80 . 4242-4248.

Ohno, S., and Yanagi, Y. (2006) Cellular tropism and adaptation of the measles virus (review, Japanese). Uirusu . 56 . 27-34.

Seki, F. Takeda, M., Minagawa, H., and Yanagi, Y. (2006) The recombinant wild-type measles virus containing a single N481Y substitution in its hemagglutinin cannot use a receptor CD46 as efficiently as that having the hemagglutinin of the Edmonston laboratory strain. J Gen Virol. 87 . 1643-1648.

Tahara, M., Takeda, M., and Yanagi, Y. (2005) Contribution of matrix and large protein genes of the measles virus Edmonston strain to growth in cultured cells as revealed by recombinant viruses. J Virol. 79 . 15218-15225.

Takeda, M., Ohno, S., Seki, F., Nakatsu, Y., Tahara, M., and Yanagi, Y. (2005) Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity. J Virol. 79 . 14346-14354.

Takeda, M., Ohno, S., Seki, F., Hashimoto, K., Miyajima, N., Takeuchi, K., and Yanagi, Y. (2005) Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells. Virus Res. 108 . 161-165.

Bouche, F. B., Steinmetz, A., Yanagi, Y., and Muller, C. P. (2005) Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy. Vaccine . 23 . 2074-2077.

Davidson, D., Shi, X., Zhang, S., Wang, H., Nemer, M., Ono, N., Ohno, S., Yanagi, Y., Veillette, A. (2004) Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation. Immunity . 21 . 707-717.

Miyajima, N., Takeda, M., Tashiro, M., Hashimoto, K., Yanagi, Y., Nagata, K., and Takeuchi, K. (2004) Cell tropism of wild-type measles virus is affected by amino acid substitutions in the P, V and M proteins, or by a truncation in the C protein. J Gen Virol. 85 , 3001-3006.

Ohno, S., Ono, N., Takeda, M., Takeuchi, K., and Yanagi, Y. (2004) Dissection of measles virus V protein in relation to its ability to block interferon- α / β signal transduction. J Gen Virol. 85 , 2991-2999.

Ishida, H., Ayata, M., Singai, M., Matsunaga, I. , Seto, Y., Katayama, Y., Iritani, N., Seya, T., Yanagi, Y., Matsuoka, O., Yamano, T., and Ogura, H. (2004) Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus. Microbiol Immunol. 48 . 277-287.

Minagawa, H., Hashimoto, K., and Yanagi Y. (2004) Absence of tumour necrosis factor facilitates primary and recurrent herpes simplex virus-1 infections. J Gen Virol . 85. 343-347.

Hashimoto, K., Minagawa, H., and Yanagi, Y. (2003) Caspase-dependent apoptosis in fulminant hepatic failure induced by herpes simplex virus in mice . J Hepatol . 39 . 773-8.

Seki, F., Ono, N., Yamaguchi, R., and Yanagi, Y. (2003) Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. J Virol . 77 . 9943-9950.

Ohno, S., Seki, F., Ono, N., and Yanagi, Y. (2003) Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus. J Gen Virol . 84 . 2381-2388.

Shingai, M., Ayata, M., Ishida, H., Matsunaga, I., Katayama, Y., Seya, T., Tatsuo, H., Yanagi, Y., and Ogura, H. (2003) Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis . J Gen Virol . 84 . 2133-2143.

Bouche, F. B., Marquet-Blouin, E., Yanagi, Y., Steinmetz, A., and Muller, C. P. (2003) Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measles. Vaccine . 21 . 2074-81.

Yanagi, Y., Ono, N., Tatsuo, H., Hashimoto, K., and Minagawa, H. (2002) Measles virus receptor SLAM (CD150) (review) . Virology . 299 . 155-161.

Hashimoto, K., Ono, N., Tatsuo, H., Minagawa, H., Takeda, M., Takeuchi, K., and Yanagi, Y. (2002) SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. J Virol . 76 , 6743-6749.

Vincent, S., Tigaud, I. , Schneider, H., Buccholz, C., Yanagi, Y., and Gerlier, D. (2002) Restriction of measles virus RNA synthesis by a mouse host cell line:trans-complementation by polymerase components or a human cellular factor(s). J Virol. 76 . 6121-6130.

Tatsuo, H., and Yanagi, Y. (2002) The morbillivirus receptor SLAM (CD150) (review) . Microbiol Immunol . 46 . 135-142.

Tanaka, K., Minagawa, H., Xie, M. F., and Yanagi, Y. (2002) The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150). Arch Virol . 147 . 195-203.

Hashimoto, K., and Yanagi, Y. (2002) Measles virus entry as examined by a recombinant virus expressing green fluorescent protein (review, Japanese). Uirusu . 52. 169-175.

Minagawa, H., Tanaka, K., Ono, N., Tatsuo, H., and Yanagi, Y. (2001) Induction of the measles virus receptor SLAM (CD150) on monocytes. J Gen Virol. 82 . 2913-2917.

Tatsuo, H., Ono, N., and Yanagi, Y. (2001) Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. J Virol . 75 . 5842-5850.

Ono, N., Tatsuo, H., Hidaka, Y., Aoki, T., Minagawa, H., and Yanagi, Y. (2001) Measles viruses on throat swabs from measles patients use SLAM (CDw150) but not CD46 as a cellular receptor. J Virol. 75 . 4399-4401.

Yanagi, Y. (2001) The cellular receptor for measles virus-elusive no more (review) . Rev Med Virol . 11 . 149-156.

Okuma, K., Matsuura, Y., Tatsuo, H., Inagaki, Y., Nakamura, M., Yamamoto, N., and Yanagi, Y. (2001) Analysis of the molecules involved in human T-cell leukemia virus type 1 entry by a vesicular stomatitis virus pseudotype bearing its envelope glycoproteins. J Gen Virol . 82 . 821-830.

Ono, N., Tatsuo, H., Tanaka, K., Minagawa, H., and Yanagi, Y. (2001) V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor. J Virol . 75 . 1594-1600.

Yanagi, Y. (2001) The cellular receptor for measles virus (review, Japanese). Uirusu. 51 . 201-208.

Tatsuo, H.,* Ono, N.,* Tanaka, K., and Yanagi, Y. (2000) SLAM (CDw150) is a cellular receptor for measles virus. Nature . 406 . 893-897. (* These authors contributed equally to this work.)

Minagawa, H., and Yanagi, Y. (2000) Latent herpes simplex virus-1 infection in SCID mice transferred with immune CD4+ T cells: A new model for latency. Arch Virol . 145 . 2259-2272.

Tatsuo, H., Okuma, K., Tanaka, K., Ono, N., Minagawa, H., Takade, A., Matsuura, Y., and Yanagi, Y. (2000) Virus entry is a major determinant of cell tropism of Edmonston and wild-type strains of measles virus as revealed by vesicular stomatitis virus pseudotypes bearing their envelope proteins. J Virol . 74 . 4139-4145.

Kimura, Y., Hayashida, K., Ishibashi, H., Niho, Y., and Yanagi, Y. (2000) Antibody-free virion titer greatly differs between hepatitis C virus genotypes. J Med Virol. 61 . 37-43.

Tatsuo, H., Ono, N., Tanaka, K., and Yanagi, Y. (2000) The cellular receptor for measles virus: SLAM (CDw 150) (review, Japanese) Uirusu. 50. 289-296.

Department of Virology,Faculty of Medicine,Kyushu University Japanese Contact