DEPARTMENT OF CARDIOVASCULAR MEDICINE KYUSHU UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES

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Research Units

Heart Failure Research Unit

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menu Research Outline Main Research Themes and Relevant Publications Principle Investigator of the group Staff and Research Focus Research Outline Main Research Themes and Relevant Publications Profile of Lead Researcher Staffs and the Research Focus 研究概要 主要なテーマと関連論文 主任研究者情報 研究室情報

Main Research Themes and Relevant Publications


  1. Mitochondrial DNA (mtDNA) damage and reactive oxygen species generation in heart failure
  2. Research related to the roles of mitochondrial transcription factor A (TFAM) in heart failure
  3. The mechanisms of anti-remodeling effects by vagal nerve stimulation

2. Research related to the roles of mitochondrial transcription factor A (TFAM) in heart failure


During a series of studies investigating the mechanisms of reactive oxygen species generation in myocardial mitochondria, we have found that mitochondrial transcription factor A (TFAM) has a protective effect for mtDNA, and that overexpression of TFAM controls myocardial remodeling and markedly improves the prognosis after myocardial infarction in mice. At present we are engaged in studies to elucidate the mechanisms of the antioxidant action of TFAM, aiming to apply these mechanisms to treatment.

TFAM-overexpressed mice with myocardial infarction

Relevant publications
  1. Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.
    J Neurosci. 2008 Aug 20;28(34):8624-34.
  2. Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, Fujiwara T, Hamasaki N, Takeshita A, Sunagawa K, Tsutsui H. Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Circulation. 2005; 2;112(5):683-90.

  1. Mitochondrial DNA (mtDNA) damage and reactive oxygen species generation in heart failure
  2. Research related to the roles of mitochondrial transcription factor A (TFAM) in heart failure
  3. The mechanisms of anti-remodeling effects by vagal nerve stimulation

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