DEPARTMENT OF CARDIOVASCULAR MEDICINE KYUSHU UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES

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Research Units

Heart Failure Research Unit

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menu Research Outline Main Research Themes and Relevant Publications Principle Investigator of the group Staff and Research Focus Research Outline Main Research Themes and Relevant Publications Profile of Lead Researcher Staffs and the Research Focus 研究概要 主要なテーマと関連論文 主任研究者情報 研究室情報

Main Research Themes and Relevant Publications


  1. Mitochondrial DNA (mtDNA) damage and reactive oxygen species generation in heart failure
  2. Research related to the roles of mitochondrial transcription factor A (TFAM) in heart failure
  3. The mechanisms of anti-remodeling effects by vagal nerve stimulation

3. The mechanisms of anti-remodeling effects by vagal nerve stimulation



We are also conducting studies from various angles to identify the mechanisms that aggravate heart failure and also how they can be treated. One of our investigations is the anti-remodeling effect of vagal nerve stimulation. Although vagal nerve stimulation has been known to improve the prognosis of heart failure in animal models, the mechanism remains unclear. We are addressing these challenges using new methodology by combining biochemical and physiological techniques with electronic spin resonance spectroscopy (collaborative study with Professor Utsumi of the Department of Pharmacology).

Relevant publications
  1. Tsutsumi T, Ide T, Yamato M, Ando M, Shiba T, Utsumi H, Sunagawa K. Effect of anaesthesia-induced alterations in haemodynamics on in vivo kinetics of nitroxyl probes in electron spin resonance spectroscopy. Free Radic Res. 2008 Apr;42(4):305-11.
  2. Tsutsumi T, Ide T, Yamato M, Kudou W, Ando M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K. Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res. 2008 Mar 1;77(4):713-21.

  1. Mitochondrial DNA (mtDNA) damage and reactive oxygen species generation in heart failure
  2. Research related to the roles of mitochondrial transcription factor A (TFAM) in heart failure
  3. The mechanisms of anti-remodeling effects by vagal nerve stimulation

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