2009年発表論文

Nakamoto, M., Muramatsu, S., Yoshida, S., Matsuda, M., Nagahama, Y. and Shibata, N. Gonadal sex differentiation and expression of Sox9a2, Dmrt1, and Foxl2 in Oryzias luzonensis. Genesis, 2009, in press.

Cui, J.Z., Shen, X.Y., Yan, Z.W., Zhao, H.B. and Nagahama, Y. Homology-modeled ligand-binding domains of medaka estrogen receptors and androgen receptors: a model system for the study of reproduction. Biochem. Biophys. Res. Comm., 380, 115-121, 2009

Senthilkumaran, B., Sudhakumari, C.C., Wang, D.S., Sreenivasulu, G., Kobayashi, T., Kobayashi, H.-K., Yoshikuni, M. and Nagahama, Y. Novel 3β-hydroxysteroid dehydrogenases from gonads of the Nile tilapia: Phylogenetic significance and expression during reproductive cycle. Mol. Cell. Endocrinol., 299, 146-152, 2009

2008年発表論文

Paul-Prasanth, B., Matsuda, M., Kobayashi, T., Suzuki, A. and Nagahama, Y. Functional analysis of the medaka sex determining gene, DMY-A minireview. Cybium, 32, 72-73, 2008

Okubo, K. and Nagahama, Y. Structural and functional evolution of gonadotropin-releasing hormone in vertebrates. Acta Physiol., 193, 3-15, 2008

Matsuoka, Y., Kobayashi, T., Kihara, K. and Nagahama, Y. Molecular cloning of Plk1 and Nek2 and their expression in mature gonads of the teleost fish Nile tilapia (Oreochromis Niloticus). Mol. Reprod. Develop., 75, 989-1001, 2008

Sakai, F., Kobayashi, T., Matsuda, M. and Nagahama, Y. Stability in aromatase immunoreactivity of steroid-producing cells during early development of XX gonads of the Nile tilapia, Oreochromis niloticus: An organ culture study. Zool. Sci., 25, 344-348, 2008

Kobayashi, T., Kajiura-Kobayashi, H., Guan, G. and Nagahama, Y. Sexual dimorphic expression of DMRT1 and Sox9 during gonadal differentiation and hormone-induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus). Dev. Dyn., 237, 297-306, 2008

Ijiri, S., Kaneko, H., Kobayashi, T., Wang, D.S., Sakai, F., Paul-Prasanth, B., Nakamura, M. and Nagahama, Y. Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus. Biol. Reprod., 78, 333-341, 2008

2007年発表論文

Zhou, L.Y., Wang, D.S., Shibata, Y., Paul-Prasanth, B., Suzuki, A. and Nagahama, Y. Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka, Oryzias latipes. Biochem. Biophys. Res. Comm., 362, 619-624, 2007

Zhou, L.Y., Wang, D.S., Kobayashi, T., Yano, A., Paul-Prasanth, B., Suzuki, A., Sakai, F. and Nagahama, Y. A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney. Endocrinology, 148, 4288-4291, 2007

Liu, Z.H., Wu, F.R., Jiao, B.W., Zhang, X.Y., Hu, C.J., Huang, B.F., Zhou, L.Y., Huang, X.G., Wang, Z.J., Zhang, Y.G., Nagahama, Y., Cheng, C.H.K and Wang, D.S. Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation. J. Endocrinol., 194, 223-241, 2007

Matsuda, M., Shinomiya, S., Kinoshita, M., Suzuki, A., Kobayashi, T., Paul-Prasanth, B., Lau, E.L., Hamaguchi, S., Sakaizumi, M. and Nagahama, Y. DMY gene induces male development in genetically female (XX) medaka fish. Proc. Natl. Acad. Sci. USA, 104,, 3865-3870, 2007

Ohmuro-Matsuyama, Y., Okubo, K., Matsuda, M., Ijiri, S., Wang, D.S., Guan, G.J., Suzuki, T., Matsuyama, M., Morohashi, K., and Nagahama, Y. Liver receptor homologue-1 activates brain aromatase promoter of medaka, Oryzias latipes. Mol. Reprod. Develop., 74, 1065-1071, 2007

Wang, D.S., Kobayashi, T., Zhou, L.Y., Paul-Prasanth, B., Ijiri, S., Sakai, F., Okubo, K., Morohashi, K. and Nagahama, Y. Foxl2 up-regulates aromatase gene transcription female-specifically by binding to the promoter as well as interacting with Ad4BP/SF-1. Mol. Endocrinol., 21, 712-725, 2007

Nakamoto, M., Wang, D.S., Suzuki, A., Matsuda, M., Nagahama, Y. and Shibata, N. Dax1 suppresses P450arom expression in medaka ovarian follicles. Mol. Reprod. Develop., 74, 1239-1246, 2007

2006年発表論文

R.K. Bhandari, M. Nakamura, T. Kobayashi, Y. Nagahama. Suppression of steroidogenic enzyme expression during androgen-induced sex reversal in Nile tilapia (Oreochromis niloticus). Gen. Comp. Endocrinol. 145, 20-24, 2006

Paul-Prasanth, B., Matsuda, M., Lau, E.L., Suzuki, A., Sakai, F., Kobayashi, T. and Nagahama, Y. Knock-down of DMY initiates female pathway in the genetic male medaka, Oryzias latipes. Biochem. Biophys. Res. Comm., 351, 815-819, 2006

K. Okubo, F. Sakai, E.L. Lau, G. Yoshizaki, Y. Takeuchi, K. Naruse, K. Aida, Y. Nagahama. Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome. Endocrinology 147, 1076-1084, 2006

Y. Oshima, T. Kato, D.S. Wang, T. Murakami, M. Matsuda, Y. Nagahama, M. Nakamura. Promoter activity and chromosomal location of the Rana rugosa P450 aromatase (CYP19) gene. Zool. Sci. 23, 79-85, 2006

M. Tokumoto, Y. Nagahama, P. Thomas, T. Tokumoto. Cloning and identification of a membrane progestin receptor in goldfish ovaries and evidence it is an intermediary in oocyte meiotic maturation. Gen. Comp. Endocrinol. 145, 101-108, 2006

D.S. Wang, B. Senthilkumaran, C.C. Sudhakumari, F. Sakai, M. Matsuda, T. Kobayashi, M. Yoshikuni, Y. Nagahama. Molecular cloning, gene expression and characterization of the third estrogen receptor of the Nile tilapia, Oreochromis niloticus. Fish Physiol.Biochem. (in press)

Y. Nagahama. Molecular mechanisms of sex determination and gonadal sex differentiation in fish. Fish Physiol. Biochem. (in press)

Y. Ohmuro-Matsuyama, K. Okubo, M. Matsuda, S. Ijiri, D.S. Wang, G.J. Guan, T. Suzuki, M. Matsuyama, K. Morohashi, Y. Nagahama. Liver receptor homologue-1 activates brain aromatase promoter of medaka, Oryzias latipes. Mol. Reprod. Develop. (in press)

C.C. Sudhakumari, B. Senthilkumaran, T. Kobayashi, H. Kajiura-Kobayashi, D.S. Wang, M. Yoshikuni, Y. Nagahama. Ontogenic expression patterns of several nuclear receptors and cytochrome P450 aromatases in brain and gonads of the Nile tilapia Oreochromis niloticus suggests their involvement in sex differentiation. Fish Physiol. Biochem. (in press)

Y. Ohmuro-Matsuyama, Y. Shibata, R. Chaube, M. Yoshikuni, K. Okubo, Y. Nagahama, S. Ijiri Roles of three transcription factors of the NR5A subfamily on estradiol 17β and gonadotropin-induced changes in Cyp19a1 expression in the ovarian follicles of the medaka, Oryzias latipes Mol. Reprod. Develop. (in press)

2005年発表論文

Zhou, L.Y., Wang, D.S., Senthilkumaran, S., Yoshikuni, M., Shibata, Y., Kobayashi, T., Sudhakumari, C.C. and Nagahama, Y. Cloning, expression and characterization of three types of 17b-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus. J. Mol. Endocrinol.35, 103-116, 2005 doi:10.1677/jme.1.01801

Kobayashi, Y., Sunobe, T., Kobayashi, T., Nagahama, Y. and Nakamura, M. Gonadal structure of the serial-sex changing fish Trimma Okinawa. Dev. Growth Differ. 47, 7-13, 2005 doi:10.1111/j.1440-169x.2004.00774.x

Nakamoto, M., Suzuki, A., Matsuda, M., Nagahama, Y. and Shibata, N. Testicular type Sox9 is not involved in sex determination, but might be in the development of testicular structures in the medaka, Oryzias latipes. Biochem. Biophys. Res. Commun.333, 729-736, 2005 doi:10.1016/j.bbrc.2005.05.158.

2004年発表論文

Kobayashi, T., Kobayashi, H. and Nagahama, Y. Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes. Dev. Dyn. 231, 518-526, 2004

Kobayashi, Y., Kobayashi, T., Nakamura, M., Sunobe, T., Morrey, C.E., Suzuki, N. and Nagahama, Y. Characterization of two types of cytochrome P450 aromatase in the serial-sex changing gobiid fish, Trimma okinawae. Zool. Sci. 21, 417-425, 2004

Senthilkumaran, B. and Nagahama, Y. A shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation. Mol. Cell. Endocrinol. 215, 11-18, 2004

Suzuki, A., Tanama, M., Nagahama, Y. and Shibata, N. Expression of aromatase mRNA and effects of aromatase inhibitor during ovarian development in the medaka, Oryzias latipes. J. Exp. Zool. 301A, 266-273, 2004

Wang, D.S., Zhou, L.Y., Kobayashi, T. and Nagahama, Y. Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus. Biochem. Biophys. Res. Commun. 320, 83-89, 2004

長濱嘉孝、小林　亨、松田　学（2004）。魚類の性決定と生殖腺の性分化/性転換。動物の性はどのように決まるか？：性決定機構の共通性と多様性。蛋白質　核酸　酵素。49、116-123．

長濱嘉孝（2004）。魚類生殖系に及ぼす影響のメカニズム。内分泌撹乱物質‐どこまでわかったか（8）。現代化学。2004年8月、40-45．