Vascular endothelium is well known to regulate the local vascular functions in response to mechanical stress. Gravity can be regarded as a continuous mechanical stress loaded to endothelium. Associate Prof. Masahiro Oike has studied the cellular mechanics, by which endothelium responds to the change of gravity, by using hypergravity. He found that integrins, which transduce extracellular environment into cell interior, sense the change of gravity. He observed that the stimulation of integrin with 3G hypergravity leads to the activation of kinases and subsequent actin fiber formation. This also implies that vascular functions would be affected in similar ways in microgravity environment in space.