Studies of a genetic polymorphism support the role of bile acids in colorectal carcinogenesis
Professor Kono and his colleagues also studied the genetic polymorphism of CYP7A1 in a case control study of 446 cases of colorectal adenoma and 914 controls of normal colonoscopy. Adenoma is a well-established precursor lesion of colorectal cancer. Again, there was no overall association between the CYP7A1 polymorphism and colorectal adenoma, but the homozygous variant of CC genotype was associated with an evident decrease in the risk of right-sided colon adenoma.
Professor Kono said, “Our findings are just a small piece of information in thinking of the fat and colon cancer story, but the remarkable consistency in two studies is a pleasant surprise.” He also added,“Epidemiology using genetic information is very useful for understanding the influence of lifestyle factors in the occurrence of cancer and other diseases.”