The patho-physiological role of vascular remodeling in the development and progression of atherosclerosis, thrombosis, proliferative diabetic retinopathy, and tumors, remains unclear. To elucidate the molecular basis of vascular remodeling and to establish the novel and effective therapy on the basis of scientific evidences, we study on the molecular mechanisms of pathological vascular remodeling, and tumorigenesis, as following fields.

1. Patho-physiological regulatory systems of vascular remodeling in angiogenic diseases.
2. Pathology of atherogenesis and progression of atherosclerosis.
3. Clinicopathologycal and pathophysiological study on nonsmall-cell lung cancer (NSCLC).

Normal tissue morphology is determined by the orderly proliferation, differentiation, and cell death of various cells comprising the tissue, and disruption of this homeostasis causes morphological changes. With a focus on malignant solid tumors, our department covers the development of pathological diagnostic methods; analysis of molecular abnormalities, such as gene mutations, epigenetic abnormalities, and gene expression abnormalities, as potential therapeutic targets; and mechanisms of carcinogenesis and tumor progression. In addition, we will engage in research on intratumor diversity and the tumor microenvironment, considering the tumor tissue a heterogeneous cell population consisting of tumor cells with various genetic abnormalities and nontumor cells.

1. Acquisition of knowledge and skills in general diagnostic pathology.
2. Acquisition of techniques for analyzing gene mutations, epigenomes, and abnormal gene expression (bioinformatics methods).
3. Spatial analysis of the morphology and molecular abnormalities of malignant tumors (image analysis).
4. Establishment of tumor cell lines and the identification of therapeutic targets using the cell lines.

With the aim of comprehensively understanding of biomolecular events in health and disease, we’re conducting data-driven research through clinical omics approaches, metabolome, lipidome, and proteome analyses via mass spectrometry, combined with a spatial transcriptome technique. Furthermore, in seamless collaboration with the hospital laboratories, we explore biomarkers associated with various diseases and contribute to development of novel clinical testing methodologies. Additionally, as cardiovascular research, we are going on a unique study by using methods that combine classical circulatory physiology approaches and state-of-the-art artificial intelligence analysis.

1. Screening and Assessing the Effectiveness of Novel Agents against Hematological Tumors.
2. Development of Comprehensive Molecular Profiling Techniques through Mass Spectrometry and their clinical application.
3. Spatial Profiling of Gene Expression in Tissues to Uncover Cellular Heterogeneity and Identify Novel Therapeutic Targets.
4. Investigating Strategies to Improving maximal oxygen uptake by high-intensity interval exercise training in the elderly patients.
5. Applying Vector Flow Mapping that visualizes left ventricular blood fluid to evaluation of cardiac functions.
6. Establishing an automatic analysis of electrocardiogram by applying deep learning and neural network analysis.

In recent years, it has become increasingly evident that gut bacteria play a significant role in maintaining human health. We are interested in the interaction between gut bacteria and the host. We are conducting research to identify bacterial strains that have a beneficial impact on various physiological functions of the host, such as the immune system, metabolism, and nervous system, with the goal of clinical applications.

1. Anaerobic culture of gut bacteria
2. Generation and maintenance of germ-free mice and gnotobiotic mice
3. Metagenomic analysis of gut microbiome
4. Generation of genetically modified bacteria strains
5. Metabolomic analysis using mass spectrometry techniques such as LC-MS/MS

We aim to advance research on viral replication and pathogenicity using various approaches, including molecular biology, cell biology, and animal models, to contribute to the prevention and treatment of infectious diseases. Currently, we are primarily conducting research on hepatitis viruses, SARS-CoV-2, flaviviruses, and respiratory syncytial virus (RSV).

1. Research contributing to the development of antiviral drugs for hepatitis B.
2. Research on the pathogenic mechanisms of SARS-CoV-2.
3. Research on the tropism of flaviviruses.
4. Research contributing to the development of antiviral drugs for respiratory syncytial virus (RSV) infection.

In the Department of Biomedicine, studies have been focused on the development of disease models and the elucidation of pathological mechanisms using experimental animals. We also conduct researches on the effect of rearing environment on disease phenotypes.

1. Analysis of effects of rearing environment on behaviors.
2. Investigation of microbiome monitoring method to ensure reproducibility of animal experiments

1. Generation of transgenic mice
2. Generation of gene targeted mouse (knockout mouse)
3. Screening of disease model marmosets using drug susceptibility
4. Evaluation of microbiome

The goal of the doctoral program in scientific pathology is to cultivate the abilities and academic knowledge necessary for independent and international research activities as a medical researcher by studying basic life science theories related to medicine and their application to advanced medical care in a highly specialized research field that integrates basic medicine and clinical medicine. Our research focuses on elucidating the origins of malignant tumors in the gastrointestinal field, and the relationship between fatty liver and vascular lesions and other malignant tumors. We are engaged in research that leads to the development of clinical diagnosis and treatment methods, incorporating genetic analysis and spatial proteomics methods.

1. Molecular abnormalities of carcinogenesis for solid tumors
2. Morphological changes caused by drugs on tissues
3. Relationship and comparison between radiological imaging and pathological characters
4. Analysis of hematological abnormalities reflecting pathomorpholical features